Journal Article10.1016/J.AMJCARD.2007.05.034
Relation of Coronary Artery Calcium to Flow-Mediated Dilation and C-Reactive Protein Levels in Asymptomatic Patients With Heterozygous Familial Hypercholesterolemia
Zhong Xuan Ye,Zhong Xuan Ye,Zhong Xuan Ye,Hao Ming Cheng,Hao Ming Cheng,Kuan Rau Chiou,Po Hsun Huang,Po Hsun Huang,Shing Jong Lin,Shing Jong Lin,Min Ji Charng,Min Ji Charng +11 more
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TL;DR: FH subjects with positive CAC scores have decreased flow-mediated dilation and increased hs-CRP levels, which is the only independent predictor of the presence of CAC.
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Abstract: The extent of coronary artery calcium (CAC) is correlated with coronary artery disease prognosis. However, the relation of CAC to endothelial function and high-sensitivity C-reactive protein (hs-CRP) in patients with asymptomatic heterozygous familial hypercholesterolemia (FH) requires clarification. The study aim was to investigate the relations among CAC, endothelial function, and hs-CRP in patients with asymptomatic heterozygous FH. Thirty-two patients with asymptomatic heterozygous FH (mean age 42 years) and 34 healthy control subjects (mean age 36 years) were enrolled. We measured CAC by electron-beam computed tomography and endothelial function by flow-mediated dilation of the brachial artery. A higher percentage of patients with FH had a positive CAC score compared with the control group. Comparing the FH group with detectable CAC (CAC score >0) and undetectable CAC (CAC score of 0), we found higher hs-CRP levels (0.29 ± 0.23 vs 0.07 ± 0.08 mg/dl, p = 0.001) and reduced flow-mediated dilation (0.04 ± 0.03 vs 0.08 ± 0.03, p = 0.005) in the detectable CAC group. Multivariate analysis showed an independent correlation of hs-CRP with detectable CAC (relative risk 5.034, 95% confidence interval 1.525 to 16.613, p = 0.04). In conclusion, FH subjects with positive CAC scores have decreased flow-mediated dilation and increased hs-CRP levels. Furthermore, hs-CRP level is the only independent predictor of the presence of CAC.
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Citations
Cardiovascular risk stratification in familial hypercholesterolaemia
TL;DR: It is essential to have a better screening programme to prioritise the candidates for treatment with the most severe form of FH and at higher risk of coronary events and the utility of new imaging techniques and new cardiovascular biomarkers remains to be determined in prospective trials.
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No correlation and low agreement of imaging and inflammatory atherosclerosis` markers in familial hypercholesterolemia
L. Martinez,Marcio H. Miname,Luiz Aparecido Bortolotto,Ana Paula Marte Chacra,Carlos E. Rochitte,Andrei C. Sposito,Raul D. Santos +6 more
TL;DR: Clinical parameters poorly explained IMT, CAC and PWV variability in FH subjects, and imaging markers and inflammatory biomarkers presented a poor agreement degree of their severity for CHD prediction.
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Update of the Brazilian Guideline for Familial Hypercholesterolemia – 2021
Maria Cristina de Oliveira Izar,Viviane Zorzanelli Rocha Giraldez,Adriana Bertolami,Raul Dias dos Santos Filho,Ana Maria Lottenberg,Marcelo Heitor Vieira Assad,José Francisco Kerr Saraiva,Ana Paula Marte Chacra,Tania Leme da Rocha Martinez,Luciana Bahia,Francisco Antonio Helfenstein Fonseca,André Arpad Faludi,Andrei C. Sposito,Antonio Carlos Palandri Chagas,Cinthia E. Jannes,Cristiane Kovacs Amaral,DB Araújo,Dennys E. Cintra,Elaine Dos Reis Coutinho,Fernando H. Y. Cesena,Hermes Toros Xavier,Isabela Cardoso Pimentel Mota,Isabela de Carlos Back Giuliano,José Rocha Faria Neto,Juliana Tieko Kato,Marcelo Chiara Bertolami,Marcio H. Miname,Maria Helane Costa Gurgel Castelo,Maria Silvia Ferrari Lavrador,Roberta Marcondes Machado,Patrícia Guedes de Souza,Renato Jorge Alves,Valéria A. Machado,Wilson Salgado Filho +33 more
TL;DR: Familial hypercholesterolemia (FH) is a common genetic cause of premature coronary artery disease (CAD), especially myocardial infarction, related to lifetime exposure to high concentrations of low-density lipoprotein cholesterol (LDL-C) as mentioned in this paper.
•Dissertation
Metabolic Regulation of Endothelial Dysfunction and Cardiovascular Risk
Joanna Mary Young
- 01 Jan 2012
TL;DR: A chronology of key events and publications related to the determinants of infectious disease and their role in human evolution is provided.
Relation of C-reactive protein and carotid intima media thickness in Taiwanese with familial hypercholesterolemia.
TL;DR: In conclusion, patients with heterozygous FH had significantly higher carotid IMT and the level of hsCRP was independently associated with atherosclerotic progression.
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