Book Chapter10.1007/978-1-60327-567-5_8
Reflectometric Interference Spectroscopy
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TL;DR: Elaborate details on instrumental realization and surface chemistry are discussed for optimum application of reflectometric interference spectroscopy (RIfS).
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Abstract: Reflectometry is classified in comparison to the commercialized refractometric surface plasmon resonance (SPR). The advantages of direct optical detection depend on a sophisticated surface chemistry resulting in negligible nonspecific binding and high loading with recognition sites at the biopolymer sensitive layer of the transducer. Elaborate details on instrumental realization and surface chemistry are discussed for optimum application of reflectometric interference spectroscopy (RIfS). A standard protocol for a binding inhibition assay is given. It overcomes principal problems of any direct optical detection technique.
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TL;DR: The intention of this article is to demonstrate the essentials of the interaction of these parts within the system, and the focus is on optical sensing using planar transducers, because fibre optical sensors have been reviewed in this journal only recently.
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TL;DR: Spectral interferometry has been used to monitor the swelling of polymers caused by organic gases or hydrocarbons in waste water as well as the adsorption and interaction of antigens and antibodies in immunoreactions.
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An integrated system for optical biomolecular interaction analysis
TL;DR: In this paper, an integrated reflectometric interference spectroscopy (RIfS) transducer was used for biomolecular interaction analysis (BIA) and the results showed that the minimum change in protein mass coverage detectable with the RIfS set-up investigated is below 2.pg protein/mm2.
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•Journal Article
Interferometric measurements used in chemical and biochemical sensors
TL;DR: In this paper, the authors present mesures interferometriques appliquees aux capteurs chimiques and biochimiques, in which l'epaisseur est midifiee par absorption d'un gaz ou par interaction avec un materiau bio-chimique, and l'utilisation of matrices de photodiodes permet d'enregister les variations de chemins optiques aussi faibles que quelques fractions de nanometre
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