Journal Article10.1039/C2PY20240A
Reduction-sensitive core-cross-linked mPEG–poly(ester-carbonate) micelles for glutathione-triggered intracellular drug release
Lesan Yan,Wenbin Wu,Wei Zhao,Ruogu Qi,Dongmei Cui,Zhigang Xie,Yubin Huang,Ti Tong,Xiabin Jing +8 more
81
TL;DR: Results indicated that the bioreducible core-cross-linked micelles can be used as drug carriers for intelligent drug delivery.
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About: This article is published in Polymer Chemistry. The article was published on 31 Jul 2012. The article focuses on the topics: Drug carrier & Micelle.
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Citations
Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance
Zhishen Ge,Shiyong Liu +1 more
TL;DR: Recent advances in stimuli-responsive block copolymer assemblies which are responsive to tumor and intracellular microenvironments and their applications in anticancer drug delivery and enhanced imaging sensitivity are summarized.
859
Aliphatic Polycarbonates from Cyclic Carbonate Monomers and Their Application as Biomaterials.
TL;DR: The synthesis, degradation, and studies into biomedical applications of aliphatic polycarbonates obtained by ring-opening polymerization of cyclic carbonate monomers (ring sizes between 6 and 8) are reviewed.
209
Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions
TL;DR: In vitro release studies showed that DOX release from PEG-P(LL18-CCA4/LA14) micelles at pH 7.4 and 37 °C was significantly inhibited by crosslinking, and core-crosslinked polypeptide micells while exhibiting high stability against extensive dilution and high salt concentration were quickly dissociated into unimers in the presence of 10 mM DTT.
186
Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly
TL;DR: These redox-responsive CCL micelles showed enhanced cytotoxicity against human breast cancer cells in vitro and exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in reduction circumstance, resulting in burst release of CPT.
169
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