Patent
Reduction of hair growth
Peter Styczynski,Gurpreet S. Ahluwalia +1 more
- 25 Nov 1996
296
TL;DR: Mammalian hair growth can be reduced by topical application of an inhibitor of fatty acid metabolism as discussed by the authors, which can be used to prevent hair growth in some cases, but not in others.
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Abstract: Mammalian hair growth can be reduced by topical application of an inhibitor of fatty acid metabolism.
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The Organic Chemistry of Drug Design and Drug Action
Richard B. Silverman
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TL;DR: The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.
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Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent
TL;DR: The structure of the geldanamycin-binding domain of Hsp90 reveals a pronounced pocket that is highly conserved across species, and the pocket's similarity to substrate-binding sites suggest that the pocket binds a portion of the polypeptide substrate and participates in the conformational maturation/refolding reaction.
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TL;DR: The control of glycosaminoglycan structure is not well understood, but it does appear to be used to change the properties of proteoglycans to suit different biological needs.
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TL;DR: A number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport, such as tunicamycin, tridecaptin, and flavomycin this paper.
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