Recovery of resting brain connectivity ensuing mild traumatic brain injury
Rose Dawn Bharath,Ashok Munivenkatappa,Suril Gohel,Rajanikant Panda,Jitender Saini,Jamuna Rajeswaran,Dhaval Shukla,Indira Devi Bhagavatula,Bharat B. Biswal +8 more
TL;DR: Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.
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Abstract: Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.
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Citations
Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks.
K A Smitha,K Akhil Raja,K M Arun,P.G. Rajesh,Bejoy Thomas,T R Kapilamoorthy,Chandrasekharan Kesavadas +6 more
TL;DR: The concept of resting state functional magnetic resonance imaging is introduced in detail, three most widely used methods for analysis are discussed, and a few of the resting state networks featuring the brain regions, associated cognitive functions and clinical applications are described.
550
Injured Brains and Adaptive Networks: The Benefits and Costs of Hyperconnectivity
TL;DR: The various ways that hyperconnectivity operates to benefit a neural network following injury while simultaneously negotiating the trade-off between metabolic cost and communication efficiency are described.
282
Detection of Mild Traumatic Brain Injury by Machine Learning Classification Using Resting State Functional Network Connectivity and Fractional Anisotropy
Victor M. Vergara,Andrew R. Mayer,Andrew R. Mayer,Eswar Damaraju,Eswar Damaraju,Kent A. Kiehl,Kent A. Kiehl,Vince D. Calhoun,Vince D. Calhoun +8 more
TL;DR: Results suggest that inclusion of both common and unique information is important for classification of mTBI and suggest that rsFNC can yield viable biomarkers that might outperform dMRI and points to connectivity to the cerebellum as an important region for the detection ofmTBI.
Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology.
TL;DR: It is proposed that long-term potentiation could represent the neurophysiological basis for the formation of highly connected nodes (hubs) and homeostatic plasticity may contribute to stabilize network activity preventing poor and excessive connectivity in the peripheral nodes.
126
Functional and Structural Network Recovery after Mild Traumatic Brain Injury: A 1-Year Longitudinal Study.
Patrizia Dall'Acqua,Sönke Johannes,Ladislav Mica,Hans-Peter Simmen,Richard Glaab,Javier Fandino,Markus Schwendinger,Christoph Meier,Erika J. Ulbrich,Andreas Müller,Hansruedi Baetschmann,Lutz Jäncke,Jürgen Hänggi +12 more
TL;DR: Brain connectivity after mild traumatic brain injury has not been investigated longitudinally with respect to both functional and structural networks together within the same patients, crucial to capture the multifaceted neuropathology of the injury and to comprehensively monitor the course of recovery and compensatory reorganizations at macro-level.
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