Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy.
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TL;DR: In this article, surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most powerful techniques based on its high sensitivity, specificity, tremendous spectral multiplexing capacity for simultaneous target detection, as well as its unique capability for obtaining intrinsic fingerprint spectra of biomolecules.
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Abstract: Traditional tissue biopsy is limited in understanding heterogeneity and dynamic evolution of tumors. Instead, analyzing circulating cancer markers in various body fluids, commonly referred to as "liquid biopsy", has recently attracted remarkable interest for their great potential to be applied in non-invasive early cancer screening, tumor progression monitoring and therapy response assessment. Among the various approaches developed for liquid biopsy analysis, surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most powerful techniques based on its high sensitivity, specificity, tremendous spectral multiplexing capacity for simultaneous target detection, as well as its unique capability for obtaining intrinsic fingerprint spectra of biomolecules. In this review, we will first briefly explain the mechanism of SERS, and then introduce recently reported SERS-based techniques for detection of circulating cancer markers including circulating tumor cells, exosomes, circulating tumor DNAs, microRNAs and cancer-related proteins. Cancer diagnosis based on SERS analysis of bulk body fluids will also be included. In the end, we will summarize the "state of the art" technologies of SERS-based platforms and discuss the challenges of translating them into clinical settings.
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Citations
Present and Future of Surface-Enhanced Raman Scattering
Judith Langer,Dorleta Jimenez de Aberasturi,Javier Aizpurua,Ramon A. Alvarez-Puebla,Baptiste Auguié,Baptiste Auguié,Jeremy J. Baumberg,Guillermo C. Bazan,Steven E. J. Bell,Anja Boisen,Alexandre G. Brolo,Jaebum Choo,Dana Cialla-May,Dana Cialla-May,Volker Deckert,Volker Deckert,Laura Fabris,Karen Faulds,F. Javier García de Abajo,Royston Goodacre,Duncan Graham,Amanda J. Haes,Christy L. Haynes,Christian W. Huck,Tamitake Itoh,Mikael Käll,Janina Kneipp,Nicholas A. Kotov,Hua Kuang,Eric C. Le Ru,Eric C. Le Ru,Hiang Kwee Lee,Jian-Feng Li,Xing Yi Ling,Stefan A. Maier,Thomas G. Mayerhöfer,Thomas G. Mayerhöfer,Martin Moskovits,Kei Murakoshi,Jwa-Min Nam,Shuming Nie,Yukihiro Ozaki,Isabel Pastoriza-Santos,Jorge Pérez-Juste,Juergen Popp,Juergen Popp,Annemarie Pucci,Stephanie Reich,Bin Ren,George C. Schatz,Timur Shegai,Sebastian Schlücker,Li-Lin Tay,K. George Thomas,Zhong-Qun Tian,Richard P. Van Duyne,Tuan Vo-Dinh,Yue Wang,Katherine A. Willets,Chuanlai Xu,Hongxing Xu,Yikai Xu,Yuko S. Yamamoto,Bing Zhao,Luis M. Liz-Marzán +64 more
TL;DR: Prominent authors from all over the world joined efforts to summarize the current state-of-the-art in understanding and using SERS, as well as to propose what can be expected in the near future, in terms of research, applications, and technological development.
Toward a New Era of SERS and TERS at the Nanometer Scale: From Fundamentals to Innovative Applications.
TL;DR: In this article , the authors report new directions and perspectives of SERS and TERS, mainly from the viewpoint of combining their mechanism and application studies, and discuss four main topics: (1) nanometer to subnanometer plasmonic hotspots for SERS, (2) Ångström resolved TERS; (3) chemical mechanisms, i.e., charge-transfer mechanism of sERS and semiconductor-enhanced Raman scattering; and (4) the creation of a strong bridge between the mechanism studies and applications.
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SERS Tags for Biomedical Detection and Bioimaging
TL;DR: The building blocks of SERS tags are introduced, followed by the summarization of recent progress in Sers tags employed for detecting biomarkers, such as DNA, miRNA, and protein in biological fluids, as well as imaging from in vitro cell, bacteria, tissue to in vivo tumors.
175
Advanced liquid biopsy technologies for circulating biomarker detection.
TL;DR: A comprehensive overview of the biogenesis, significance and potential role of four widely known biomarkers (CTCs, ctDNA, miRNA and exosomes) in cancer diagnostics and therapeutics is provided.
157
Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis.
TL;DR: The most recent developments in the isolation and analysis of circulating tumor biomarkers have been summarized, and the potential of non-blood liquid biopsy in tumor diagnostics has been discussed.
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References
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
36.3K
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
13.2K
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Shuming Nie,Steven R. Emory +1 more
TL;DR: In this article, surface-enhanced Raman scattering was used to detect single molecules and single nanoparticles at room temperature with the use of surface enhanced Raman, and the intrinsic Raman enhancement factors were on the order of 10 14 to 10 15, much larger than the ensemble-averaged values derived from conventional measurements.
10.4K
Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
Katrin Kneipp,Katrin Kneipp,Yang Wang,Yang Wang,Harald Kneipp,Harald Kneipp,Lev T. Perelman,Lev T. Perelman,Irving Itzkan,Irving Itzkan,Ramachandra R. Dasari,Ramachandra R. Dasari,Michael S. Feld,Michael S. Feld +13 more
TL;DR: In this article, the first observation of single molecule Raman scattering was made using a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about $2.
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