Recent advances in radiotherapy and its associated side effects in cancer—a review
Gomathi Mohan,Ayisha Hamna T P,Jijo A J,Saradha Devi K M,Arul Narayanasamy,Balachandar Vellingiri +5 more
TL;DR: The physiological and genetic risks associated with the cancer patients undergoing RT are spotlighted and the course of RT in most prevalent cancers tailored with dosage distribution is illustrated.
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Abstract: Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades. Though RT is a momentous adjuvant non-invasive technique, it leaves behind some unsympathetic effects. Research is going on to surmount these pessimistic sides of RT. We made a mini review of recent articles from the period of 2000 to 2017 regarding radiotherapy and its side effects in various types of cancers. The literature review was done by searching in PUBMED, MEDLINE, and SCOPUS. Here, we spotlight the physiological and genetic risks associated with the cancer patients undergoing RT. We illustrated the course of RT in most prevalent cancers tailored with dosage distribution. Radiation-induced mutation in the patients undergoing RT has been shown with evidence. Further, the major drawbacks like the development of radiation resistance in cancerous cells and secondary malignancies have been discussed. The problems associated with radiation dosage in terms of infertility and rejuvenation of reproductive cells has also been discussed. Finally, we discussed the latest treatment stratagem of RT in cancer. Cancer treatment will not be accomplished devoid of radiotherapy. But we can brace RT using radiosensitizers and ayurvedic radioprotectors.
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References
Optimal Radiation Therapy for Small Cell Lung Cancer.
TL;DR: In the last few years stereotactic ablative radiation therapy followed by chemotherapy has emerged as a promising treatment for stage I small cell lung cancer.
15
Preferential reduction of dicentrics in reciprocal exchanges due to the combination of the size of broken chromosome segments by radiation
Wei Zhang,Wei Zhang,Isamu Hayata +2 more
TL;DR: It was suggested that there was a special mechanism causing preferential reduction of dicentrics in reciprocal exchanges originated from the heteromorphic size of broken chromosomes in the last combination.
Review structure- and dynamics-based computational design of anticancer drugs.
TL;DR: Several recent drug design efforts on a selected set of targets (topoisomerases, Ras proteins, protein kinases, and histone deacetylases) toward cancer treatment and cancer prevention are summarized.
14
Delayed Numerical Chromosome Aberrations in Human Fibroblasts by Low Dose of Radiation
TL;DR: Examination of the effect of X-irradiation on delayed induction of numerical chromosomal aberrations in normal human fibroblasts irradiated with 20, 50 and 100 cGy ofX-rays using the micronucleus-centromere assay indicates that low-dose of X to induce delayed aneuploidy of chromosomes 1 and 4 in normal fibro Blasts.
13
Adjuvant vaginal brachytherapy as a part of management in early endometrial cancer
TL;DR: Optimal management should minimize intervention instead of aggressive approach, as showed by recent studies, and there is a role for brachytherapy as an adjuvant irradiation in early endometrial cancer.
12