Journal Article10.1021/ACSCATAL.0C03958
Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes
Alexia N. Kim,Brian M. Stoltz +1 more
160
TL;DR: This Perspective highlights recent advances in homogeneous catalysis of heteroarene hydrogenation as inspiration for the further development of asymmetric hydrogenation catalysts, and addresses underdeveloped areas and limitations of the current technology.
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Abstract: The asymmetric hydrogenation of heteroarenes has recently emerged as an effective strategy for the direct access to enantioenriched, saturated heterocycles. Although several homogeneous catalyst sy...
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Citations
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
TL;DR: The use of catalytic asymmetric hydrogenation (AH) in the synthesis of chiral amines bearing a stereogenic center either in the α, β, or γ position with respect to the nitrogen atom is discussed in this paper.
256
Chiral Tridentate Ligands in Transition Metal-Catalyzed Asymmetric Hydrogenation.
TL;DR: A review of chiral tridentate ligands for homogeneous asymmetric hydrogenation can be found in this article, where the philosophy of ligand design and the reaction mechanisms are highlighted and discussed.
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Late-Stage Diversification: A Motivating Force in Organic Synthesis.
TL;DR: In this article, the authors discuss their experience using late-stage diversification as a guiding principle for the synthesis of natural product analogs and reflect on the impact such efforts have on the future of complex molecule synthesis.
73
Recent developments in enantio- and diastereoselective hydrogenation of N-heteroaromatic compounds.
TL;DR: This review provides an analysis of the recent developments in the enantioselective and diastereoselectives hydrogenation of N-heteroaromatic compounds.
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