Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis
TL;DR: The importance of Rab35‐dependent membrane trafficking in cancer progression is discussed and the known functions in membrane trafficking and signaling, cell division and cell migration in cancer cells are reviewed.
read more
Abstract: Rab35 is a small GTPase that is involved in many cellular processes, including membrane trafficking, cell polarity, lipid homeostasis, immunity, phagocytosis and cytokinesis. Recent studies showed that activating mutations confer Rab35 with oncogenic properties. Conversely, downregulation of Rab35 inverts apico-basal cell polarity and promotes cell migration. Here we review Rab35's known functions in membrane trafficking and signaling, cell division and cell migration in cancer cells and discuss the importance of Rab35-dependent membrane trafficking in cancer progression.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Endocytosis in the context-dependent regulation of individual and collective cell properties
Sara Sigismund,Sara Sigismund,Letizia Lanzetti,Giorgio Scita,Pier Paolo Di Fiore,Pier Paolo Di Fiore +5 more
TL;DR: In this paper, the authors discuss recent advancements in these areas, highlighting how endocytic trafficking impacts complex cell properties, including cell polarity and collective cell migration, and the relevance of these mechanisms to disease, in particular cancer.
82
Rab GTPases: Emerging Oncogenes and Tumor Suppressive Regulators for the Editing of Survival Pathways in Cancer
Priya Darshini Gopal Krishnan,Priya Darshini Gopal Krishnan,Emily Golden,Eleanor A. Woodward,Nathan J. Pavlos,Pilar Blancafort,Pilar Blancafort +6 more
TL;DR: Deconstructing the signaling mechanisms modulated by Rab proteins during apoptosis could unveil underlying molecular mechanisms that may be exploited therapeutically to selectively target malignant cells.
77
Extracellular vesicles and particles impact the systemic landscape of cancer
TL;DR: The multifaceted roles of EVPs in cancer are highlighted, including how exploiting the highly selective enrichment of molecules within EVPs has profound implications for advancing diagnostic and prognostic biomarker development and for improving therapy delivery in cancer patients.
69
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
Gopinath Kulasekaran,Mathilde Chaineau,Valerio Emilio Crescenzo Piscopo,Federica Verginelli,Maryam Fotouhi,Martine Girard,Yeman Tang,Rola Dali,Rita Lo,Stefano Stifani,Peter S. McPherson +10 more
TL;DR: A novel GTPase cascade in which Arf5 activates Rab35 increases EGF receptor activation, leading to upregulation of the transcription factor SPOCD1 with enhanced tumor growth and invasion in glioblastoma.
RAB39A: a Rab small GTPase with a prominent role in cancer stemness.
Tokuhiro Chano,Sofia Avnet +1 more
TL;DR: Current knowledge on the oncogenic function of RAB 39A is provided, the effect of different microenvironments on RAB39A activity and subcellular localization in cancer cells is summarized and the results show cancer stemness and tumorigenesis are promoted.
References
Clonal evolution in cancer
Mel Greaves,Carlo C. Maley +1 more
TL;DR: The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.
3K
Pan-cancer patterns of somatic copy number alteration
Travis I. Zack,Travis I. Zack,Steven E. Schumacher,Steven E. Schumacher,Scott L. Carter,Andrew D. Cherniack,Gordon Saksena,Barbara Tabak,Michael S. Lawrence,Cheng-Zhong Zhang,Jeremiah Wala,Craig H. Mermel,Carrie Sougnez,Stacey Gabriel,Bryan Hernandez,Hui Shen,Peter W. Laird,Gad Getz,Matthew Meyerson,Rameen Beroukhim +19 more
TL;DR: The Cancer Genome Atlas Pan-Cancer data set was used in this article to investigate the role of SCNAs in cancer-related SCNA patterns, including whole-genome doubling, TP53 mutations, CCNE1 amplifications and alterations of PPP2R complex.
ARF proteins: roles in membrane traffic and beyond.
TL;DR: The understanding of the signalling pathways that are regulated by ARF1 and ARF6, two of the best characterized ARF proteins, provide a molecular context for ARF protein function in fundamental biological processes, such as secretion, endocytosis, phagocyTosis, cytokinesis, cell adhesion and tumour-cell invasion.
1.4K
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53 -null cells
Takeshi Fujiwara,Madhavi Bandi,Masayuki Nitta,Elena Ivanova,Roderick T. Bronson,David Pellman +5 more
TL;DR: Tetraploidy enhances the frequency of chromosomal alterations and promotes tumour development in p53-/- MMECs, and MMP overexpression is linked to mammary tumours in humans and animal models.
1.1K
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Chieh Hsu,Yuichi Morohashi,Shin-ichiro Yoshimura,Natalia Manrique-Hoyos,SangYong Jung,Marcel A. Lauterbach,Mostafa Bakhti,Mads Grønborg,Wiebke Möbius,Jeong-Seop Rhee,Francis A. Barr,Mikael Simons +11 more
TL;DR: A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.