Patent
Pseudotypage des vecteurs vih-1 par des enveloppes de rhabdovirus
Chamsy Sarkis,Yi He,Che Serguera,Noelle Dufour,Jacques Mallet +4 more
- 31 May 2002
TL;DR: The authors decrit un lentivirus defectif pseudotype avec une enveloppe de lyssavirus, par exemple de type PV (virus de la Rage) ou MOK(virus Mokola) ainsi que ses utilisations notamment for la preparation d'une composition destinee au transfert de genes dans des astrocytes in vivo and egalement for le traitement de desordres du systeme nerveux central.
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Abstract: L'invention decrit un lentivirus defectif pseudotype avec une enveloppe de lyssavirus, par exemple de type PV (virus de la Rage) ou MOK (virus Mokola) ainsi que ses utilisations notamment pour la preparation d'une composition destinee au transfert de genes dans des astrocytes in vivo et egalement pour le traitement de desordres du systeme nerveux central.
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References
Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
Nicholas D. Mazarakis,Mimoun Azzouz,Jonathan Rohll,Fiona Margaret Ellard,Fraser J. Wilkes,Anna L. Olsen,Emma E. Carter,Robert D. Barber,Dilair F. Baban,Susan Mary Kingsman,Alan J. Kingsman,Karen L. O'Malley,Kyriacos Mitrophanous +12 more
TL;DR: Long-term expression was observed after gene transfer in the nervous system and a minimal immune response which, together with the possibility of non-invasive administration, greatly extends the utility of lentiviral vectors for gene therapy of human neurological disease.
Stable gene transfer to the nervous system using a non-primate lentiviral vector
Kyriacos A. Mitrophanous,Soonsang Yoon,Jonathan Rohll,D Patil,Fraser J. Wilkes,V N Kim,Susan M. Kingsman,Susan M. Kingsman,A J Kingsman,A J Kingsman,Nicholas D. Mazarakis +10 more
TL;DR: This system is able to transduce both dividing and non-dividing cells, including primary cultured hippocampal neurons and neurons and glia in the adult rat central nervous system, at efficiencies comparable with HIV-based vectors.
310
Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins.
Nathalie Desmaris,Assumpció Bosch,Christine Salaün,Caroline Petit,Marie-Christine Prévost,Noël Tordo,Pierre Perrin,Olivier Schwartz,Hugues de Rocquigny,Jean Michel Heard +9 more
TL;DR: Although coating HIV-1 particles with rabdhovirus envelope glycoproteins enables them to enter neuronal cells efficiently, pseudotyping is not sufficient to confer the powerful neurotropism of lyssaviruses to lentivirus vectors.
142
Patent
Retroviral delivery system
Kyriacos Andreou Mitraphanous,Deva Patil,Alan J. Kingsman,Susan M. Kingsman,F M Ellard +4 more
- 21 May 1999
TL;DR: In this article, a retroviral delivery system capable of transducing a target site is described, which comprises a first nucleotide sequence coding for at least a part of an envelope protein; and one or more other nucleotide sequences derivable from a retro-virus that ensure transduction of the target site by the retrovirus delivery system.
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The 19th Annual National Neurotrauma Society Symposium, A Satellite to 31st Annual Meeting of the Society for Neuroscience San Diego Marriott Hotel and Marina, San Diego, CA November 9–10, 2001
TL;DR: The 19th Annual National Neurotrauma Symposium was held as a satellite meeting to the 31st Annual Meeting of the Society for Neuroscience in San Diego, CA on November 9 and 10, 2001 and dealt with the new therapeutic approaches to head and spinal cord trauma.
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