Progress of tubulin polymerization activity detection methods

TL;DR: Wang et al. as discussed by the authors designed, synthesized and evaluated as tubulin polymerization inhibitors targeting the colchicine binding site, and showed that compound MY-413 was a promising lead compound for the further investigation as a potential anti-gastric cancer agent.

TL;DR: The significance of microtubules as a potential pharmacological target for cancer is discussed and the necessity of finding new microtubule inhibitors to fight the disease is stressed.

TL;DR: Wang et al. as discussed by the authors reported a novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo.

TL;DR: In this article , the authors reviewed the reports on tubulin degradation, and focused on the degradation mechanism and important functional groups of chemically synthesized compounds, hoping to provide help for the degradation design of tubulin.

TL;DR: There is poor agreement between tools for clinical assessment of MTA-associated peripheral neuropathy, and standardization of grading scales is needed to reduce variability.

TL;DR: SKLB0533 inhibited tubulin polymerization, arrested the cell cycle at the G2/M phase and induced apoptosis in CRC cells, and suppressed tumour growth in the HCT116 xenograft model without inducing notable major organ-related toxicity.

TL;DR: Recent advances in correlative light microscopy and cryoET are reviewed and major findings made available by applying this method are discussed.

TL;DR: It is believed that the steady presence and constant physiological role of microtubules are responsible for the overall success of MTAs, and the clinical disappointment of mitosis-specific inhibitors stands as evidence that MTAs have been successful not only by interfering with mitosis but, more importantly, by disrupting essential interphase cellular mechanisms.