Journal Article10.54762/ccr2024.943-951
Progress of network pharmacology-based research on Chinese medicine compounds for hyperuricemia
Zhongyu Wang,Hongzong Si +1 more
About: This article is published in Cancer cell research. The article was published on 26 Jun 2024. The article focuses on the topics: Hyperuricemia & Medicine.
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Figures
![Fig. 1. Cyberpharmacology process (using the example of Si Miao Pill)[10]](/figures/figure1-1-17esq7woqjmt.webp)
References
Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.
TL;DR: In this paper , the authors summarized the present application status and existing problems of network pharmacology in the field of Chinese medicine formula, and formulates the research ideas, up-to-date key technology and application method and strategy.
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Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease.
TL;DR: In this article, the authors suggest a pathogenic role of hyperuricemia in the development of chronic kidney disease (CKD) and cardiovascular diseases (CVD), by inducing inflammation, endothelial dysfunction, proliferation of vascular smooth muscle cells, and activation of the renin-angiotensin system.
297
Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease.
Claudio Borghi,Enrico Agabiti-Rosei,Richard J. Johnson,Jan T. Kielstein,E. Lurbe,Giuseppe Mancia,Josep Redon,Austin G. Stack,Konstantinos Tsioufis +8 more
TL;DR: Uric acid is emerging as a potentially treatable risk factor for cardiometabolic diseases, and more clinical trials investigating the potential benefit of lowering serum uric acid are recommended in individuals with hyperuricaemia.
267
The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies.
Jing Wang,Yong Chen,Yong Chen,Hao Zhong,Fang Chen,Joe M. Regenstein,Xiaosong Hu,Luyun Cai,Fengqin Feng +8 more
TL;DR: In this paper, the relationship between hyperuricemia and the gut microbiota is elucidated, and anti-hyperuricemic mechanisms targeting the intestine are discussed, such as the promotion of purine and UA catabolism by the Gut microbiota, increases in UA excretion by the gut metabolites, regulation of UA absorption or secretion in the intestinal tract by certain transporters.
177
Hyperuricemia and Cardiovascular Disease.
Shuangshuang Zhang,Yong Wang,Jinsong Cheng,Ning Huangfu,Ruochi Zhao,Zhenyu Xu,Fuxing Zhang,Wenyuan Zheng,Dandan Zhang +8 more
TL;DR: The possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan are discussed.
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