Journal Article10.1002/ange.202203800
Programming Receptor Clustering with DNA Probabilistic Circuits for Enhanced Natural Killer Cell Recognition
Mingshu Xiao,Wei Lai,Xiaowei Yao,Hao Pei,Chunhai Fan,Li Li +5 more
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TL;DR: In this paper , the authors proposed to use receptor clustering on membrane with DNA probabilistic circuits to enhance the recognition ability of immune cells for cell-based cancer immunotherapy and showed that the generated receptor clusters showed higher binding affinity to target cancer cells and improved membrane-anchoring stability compared with monomers.
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Abstract: Developing strategies to enhance the recognition ability of immune cells is important to the success of cell-based cancer immunotherapy. Herein, we report programming receptor clustering on membrane with DNA probabilistic circuits for enhanced immune cell recognition. By designing the circuit output to activate receptors for binding to adjacent receptors, we can engineer DNA probabilistic circuits for programmable regulation of receptor clustering. The generated receptor clusters show higher binding affinity to target cancer cells and improved membrane-anchoring stability compared with monomers. We demonstrate that programming receptor clustering could allow to modulate the recognition capability of natural killer cells and control natural killer cell-cancer cell interactions to promote efficient cancer cell killing. This work provides insights for precise control over cellular recognition and opens new opportunities for the development of cell-based immunotherapy.
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Citations
Designer cellular spheroids with DNA origami for drug screening
Jiayi Wei,Yueyang Sun,H. Wang,Tong Zhu,Li Li,Ying Zhou,Quan Liu,Zhen Dai,Wenjuan Li,Taihua Yang,Bingmei Wang,Chengfeng Zhu,Xizhong Shen,Qunyan Yao,Guangqi Song,Yicheng Zhao,Hao Pei +16 more
TL;DR: This work introduces a method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, to create spheroids with a customizable 3D layout, which achieves a high level of biological fidelity while being standardized and straightforward to construct with the potential for large-scale drug discovery applications.
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Modular DNA-origami-based nanoarrays enhanced cell binding-affinity through “lock-key” interaction
18 Oct 2022
TL;DR: Wang et al. as discussed by the authors developed modular DNA-origami-based nanoarrays with multivalent aptamers to match the spatial distribution of target protein clusters and avoid potential steric hindrance.
Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly
Lingzhi Cao,Xinjian Yang,Yimei Li,Huamin Liang,Q. Liu,Massimo Bottini,Y. Jin,Jiyu Wang,Jinchao Zhang,Xing‐Jie Liang +9 more
TL;DR: Near-infrared light-activatable DNA tentacles for efficient inhibition of tumor metastasis by bio-orthogonal cell assembly efficiently inhibits tumor metastasis by forming a cross-linked network and enhancing immune response.
Designer Cellular Spheroids with DNA Origami for Drug Screening
Hao Pei,Jiayi Wei,Yueyang Sun,Heming Wang,Tong Zhu,Li Li,Ying Zhou,Quan Liu,Zhen Dai,Wenjuan Li,Taihua Yang,Bingmei Wang,Chunyin Zhu,Xin Shen,Qunyan Yao,Guangqi Song,Yicheng Zhao +16 more
- 15 Dec 2023
TL;DR: Designer cellular spheroids with DNA origami for drug screening provide a novel method to create complex human tissues for drug testing, improving accuracy and efficiency.
Improving Dynamic Control of Toehold-Mediated Strand Displacement Reactions through Phosphorothioate Modifications
Ruyi Liang,Yiyang Shen,Timothy E. Long,Peilin Yang,Chuanrui Xu,Tongbo Wu,Mingxia Zhang +6 more
TL;DR: Researchers investigate phosphorothioate modifications to improve dynamic control of toehold-mediated strand displacement reactions, a crucial process in DNA nanodevices, by optimizing toehold region length and reaction velocity.
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