Journal Article10.18632/oncotarget.8353
Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas
Marjolijn D. Trietsch,Maaike Henrike Marije Oonk,Lukas JAC Hawinkels,Rosalie Bor,Jaap D.H. van Eendenburg,Zina Ivanova,Alexander A.W. Peters,Hans W. Nijman,Katja N. Gaarenstroom,Tjalling Bosse +9 more
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TL;DR: This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's, where the highest expression was observed in spindle-shaped cells, where it might be correlated to their invasive capacity.
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Abstract: Background Vulvar cancer treatment is mostly curative, but also has high morbidity rates. In a search for markers that can identify patients at risk of metastases, we investigated the prognostic value of L1-cell adhesion molecule (L1CAM) in large series of vulvar squamous cell carcinomas (VSCCs). L1CAM promotes cell motility and is an emerging prognostic factor for metastasis in many cancer subtypes. Results L1CAM expression was observed at the invasive front or in spray-patterned parts of 17% of the tumours. L1CAM-positive tumours expressed vimentin more often, but L1CAM expression was not associated with TP53 or CTNNB1 mutations. Five-year survival was worse for patients with L1CAM expression (overall survival 46.1% vs 63.6%, P=.014, disease specific survival 63.8% vs 80.0%, P=.018). Multivariate analysis indicates L1CAM expression as an independent prognostic marker (HR 2.9, 95% CI 1.10–7.68). An in vitro spheroid invasion assay showed decreased invasion of L1CAM-expressing VSCC spindle cells after treatment with L1CAM-neutralising antibodies. Materials and Methods Paraffin-embedded tumour tissue from two cohorts (N=103 and 245) of primary VSCCs were stained for L1CAM, vimentin and E-cadherin. Patients of the first cohort were tested for human papilloma virus infection and sequenced for TP53 and CTNNB1 (β-catenin) mutations. The expression of L1CAM was correlated to clinical characteristics and patient survival. Conclusion This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's. L1CAM-expressing VSCCs had a significantly worse prognosis compared to L1CAM-negative tumours. The highest expression was observed in spindle-shaped cells, where it might be correlated to their invasive capacity.
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Citations
Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.
Hiroki J. Nakaoka,Zen-ichi Tanei,Toshiro Hara,J S Weng,Akane Kanamori,Tetsuro Hayashi,Hiroshi Sato,Akira Orimo,Kazutaka Otsuji,Keiichiro Tada,Teppei Morikawa,T. Sasaki,Masashi Fukayama,Motoharu Seiki,Yoshinori Murakami,Takeharu Sakamoto +15 more
- 15 May 2017
TL;DR: Mint3 in fibroblasts might be a good target for cancer therapy by regulating cancer cell-stromal cell communication and promoting cancer cell proliferation in vitro and tumour growth via Mint3 and L1CAM.
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Endoglin and squamous cell carcinomas
S K Hakuno,Stef Gt Janson,Marjolijn D. Trietsch,Eveline S.M. de Jonge-Muller,Stijn Crobach,Tom J. Harryvan,Jurjen J. Boonstra,Winand N.M. Dinjens,Marije Slingerland,Lukas J. A. C. Hawinkels +9 more
TL;DR: In this article , the role of endoglin on endothelial cells has been extensively described, but its expression and biological role on (epithelial) cancer cells is still debatable, especially its function on squamous cell carcinoma (SCC) cells is largely unknown.
L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer
Marlies Schrevel,Willem E. Corver,Margit E Vegter,Natalja T. ter Haar,E.J. Dreef,J.J. Beltman,Gemma G. Kenter,Tjalling Bosse,Cornelis D. de Kroon,Ekaterina S. Jordanova +9 more
TL;DR: L1CAM might be a promising new prognostic marker for locoregional recurrences in cervical cancer, and its association with vimentin expression suggests that L1Cam might affect tumor aggressiveness, possibly through EMT.
Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer
Mariem A Elfeky,Ola A. Harb,Basant Sh El Shafaay,Ahmed A. Obaya,Amr A. Awd,Mohamed M. Alkilany,Loay M. Gertallah +6 more
TL;DR: In this paper, NUSAP1, MELK, and L1CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates and higher recurrence rate after successful therapy.
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