Open AccessJournal Article
Prognostic factors associated with radiotherapy of squamous cell carcinoma of the nasal plane in cats.
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TL;DR: Results of the study indicated that cats with squamous cell carcinoma of the nasal plane benefit from radiotherapy and that treatment might be improved by increasing the radiation dose as well as altering the dose-fractionation scheme.
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Abstract: Ninety cats were irradiated for treatment of squamous cell carcinoma of the nasal plane. The 1- and 5-year progression-free survival rates were 60.1 +/- 5.5% and 10.3 +/- 6.2%, respectively. Analysis of progression-free survival times revealed that clinical stage and tumor proliferative fraction (estimated by the use of a proliferating cell nuclear-antigen immunohistochemical method) had significant prognostic value. Conversely, coat color, presence of multiple facial carcinomas, histologic grade, and feline immunodeficiency virus infection status were not found to have prognostic value. Acute radiation reactions were mild and self-limiting. Severe chronic radiation reactions were more frequent in cats infected with feline immunodeficiency virus. Results of the study indicated that cats with squamous cell carcinoma of the nasal plane benefit from radiotherapy and that treatment might be improved by increasing the radiation dose as well as altering the dose-fractionation scheme.
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Citations
Tumors of the Skin and Soft Tissues
Michael H. Goldschmidt,Mattie J. Hendrick +1 more
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The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Marie-Catherine Vozenin,Pauline de Fornel,Kristoffer Petersson,Vincent Favaudon,Maud Jaccard,Jean François Germond,Benoit Petit,Marco Burki,Gisele Ferrand,David Patin,Hanan Bouchaab,Mahmut Ozsahin,François Bochud,Claude Bailat,Patrick Devauchelle,Jean Bourhis +15 more
TL;DR: The results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLash-RT in human patients.
Measuring tumor hypoxia
TL;DR: A review of the techniques for measuring tissue oxygenation is presented with an emphasis on clinical results, and the possibility that hypoxia is not an independent variable in determining the outcome of radiation therapy is presented.
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Influence of tumor cell proliferation and sex-hormone receptors on effectiveness of radiation therapy for dogs with incompletely resected meningiomas
TL;DR: The value of irradiation for dogs with incompletely resected meningiomas is confirmed and progesterone receptors in some tumors may be responsible for an increase in PFPCNA index and may indirectly affect prognosis after radiation therapy.
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