Book Chapter10.1007/978-981-10-1061-3_14
Primary Extragastrointestinal Stromal Tumours in the Hepatobiliary Tree and Telocytes
Somanath Padhi,Hemanta K. Nayak +1 more
10
TL;DR: There seems to be a direct link between these enigmatic stromal cells and pathogenesis of gallstones and origin of EGISTs, and a hope for targeted therapies and the possible role of telocytes in hepatic regeneration and liver fibrosis opens a new dimension for futuristic research.
read more
Abstract: The first decade of the twenty-first century witnessed the presence and light microscopic, immunophenotypic, and ultrastructural characterization of interstitial Cajal-like cells (coined as ‘telocytes’) in virtually every extragastrointestinal site of the human body by Laurentiu M Popescu and his co-workers Not surprisingly, stromal tumours, immunophenotypically similar to that of telocytes [CD117 (c-KIT) +/CD34 +], have also been sporadically reported outside the tubular gut (so-called extragastrointestinal stromal tumours, EGISTs), including the gall bladder, liver, and pancreas A meticulous literature search from January 2000 to November 2015 have found 9 such case reports of EGISTs in the gall bladder, 16 in the liver, and 31 occurring in the pancreas The site wise mean age at presentation for these tumours were reported to be 622 ± 166, 509 ± 201, and 553 ± 143 years, respectively Six of nine EGISTs in the gall bladder were associated with gallstones On pathological evaluation, these tumours exhibited prominent spindled cell morphology and consistent expression of CD117/c-KIT and CD34 on immunohistochemistry and variable expression of vimentin and α-smooth muscle actin The biological behaviour of hepatic and pancreatic lesions was favourable compared to that in the gall bladder, following definitive surgery with or without imatinib therapy While the exact pathophysiologic role played by telocytes in various organs is yet to be fully elucidated, there seems to be a direct link between these enigmatic stromal cells and pathogenesis of gallstones and origin of EGISTs, and a hope for targeted therapies Furthermore, the possible role of telocytes in hepatic regeneration and liver fibrosis opens a new dimension for futuristic research
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".
TL;DR: The most commonly described telocyte-associated diseases (which may be best termed “telocytopathies” in the future) are summarized in this critical review.
60
Telocytes and interstitial cells of Cajal in the biliary system
Lei Chen,Baoping Yu +1 more
TL;DR: A novel type of interstitial tissue cells in the biliary tree termed telocytes (TCs), formerly known as interstitial Cajal‐like cells (ICLCs), exhibits very particular features which unequivocally distinguish these cells from interstitial cells of Cjal (ICCs) and other interstitial cell types.
11
Los telocitos en la biología cutánea: revaluación.
TL;DR: The telocytes (TCs) are novel interstitial cells that have been overlooked for a long time due to their histologic similarity to other stromal cells as discussed by the authors , and they are also involved in signal transduction either through their direct interactions with the neighboring cells or through paracrine signaling via extracellular vesicles.
6
Telocytes in cutaneous biology: a reappraisal.
TL;DR: The telocytes (TCs) are novel interstitial cells that have been overlooked for a long time due to their histologic similarity to other stromal cells as discussed by the authors , and they are also involved in signal transduction either through their direct interactions with the neighboring cells or through paracrine signaling via extracellular vesicles.
5
Extragastrointestinal stromal tumour of the lesser omentum: A case report and literature review
I.E. Katsoulis,A. Tzortzopoulou,P. Tziakou,N. Arnogiannaki,I. Kostoglou-Athanassiou,G. Lypas,I.G. Karaitianos +6 more
TL;DR: EGISTs are very rare mesenchymal tumours which originate from cells outside the gastrointestinal tract and tend to have an aggressive biological behaviour and is the most effective treatment associated with the use of imatinib in the presence of adverse prognostic factors.
4
References
Diagnosis of gastrointestinal stromal tumors: A consensus approach.
Christopher D.M. Fletcher,Jules J. Berman,Christopher L. Corless,Fred Gorstein,Jerzy Lasota,B. Jack Longley,Markku Miettinen,Timothy J. O'Leary,Helen Remotti,Brian P. Rubin,Barry M. Shmookler,Leslie H. Sobin,Sharon W. Weiss +12 more
TL;DR: Key elements of the consensus are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time.
3.7K
Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis
Markku Miettinen,Jerzy Lasota +1 more
TL;DR: GISTs usually occur in older adults and rarely in children in the second decade and are believed to originate from interstitial cells of Cajal or related stem cells; small intestinal tumors behave more aggressively than gastric tumors with similar parameters.
1.4K
TELOCYTES – a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal‐Like Cells (ICLC) to TELOCYTES
TL;DR: EM and cell cultures revealed very particular features of ICLC, which unequivocally distinguishes them from ICC and all other interstitial cells: the presence of 2–5 cell body prolongations that are very thin (less than 0.2 μm, under resolving power of light microscopy), extremely long (tens to hundreds of μm), with a moniliform aspect (many dilations along), as well as caveolae.
583
Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome.
TL;DR: The clinicopathologic features of 48 tumors that were histologically similar to gastrointestinal stromal tumors but occurred in the soft tissues of the abdomen were analyzed to determine their overall similarity to their gastrointestinal counterpart, their biologic behavior, and the parameters that predict risk for adverse outcome.
562
Resistance to Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors
TL;DR: The molecular basis of GIST response and/or resistance to TKIs is reviewed, strategies to prevent and/ or overcome drug resistance are discussed, and concepts are directly relevant to the development of targeted molecular therapy for other solid tumors.
229
Related Papers (5)
[...]