Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review.
TL;DR: Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications and the pharmacokinetics, bioavailability, and the safety issues of ginger are discussed in this update.
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Abstract: Zingiber officinale (ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data from in vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, and improved carbohydrate and lipid metabolism. The most active ingredients in ginger are the pungent principles, gingerols, and shogaol. Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications. The pharmacokinetics, bioavailability, and the safety issues of ginger are also discussed in this update.
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Citations
Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds
Cicero Lee-Tian Chang,Yenshou Lin,Arlene P. Bartolome,Arlene P. Bartolome,Yi-Ching Chen,Shao Chih Chiu,Wen-Chin Yang +6 more
TL;DR: Blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, β-cell function, GLP-1 homeostasis, and glucose (re)absorption are selected and discussed.
•Journal Article
Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities.
TL;DR: This review focused on the therapeutics effects of ginger and its constituents in the diseases management, and its impact on genetic and metabolic activities.
265
Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials
TL;DR: The present treatise reviews all the experimentally validated health benefits of this spice, to make a claim on its nutraceutical application.
245
The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus
Tahereh Arablou,Naheed Aryaeian,Majid Valizadeh,Faranak Sharifi,AghaFatemeh Hosseini,Mahmoud Djalali +5 more
TL;DR: Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE2 in type 2 diabetic patients, and can be considered as an effective treatment for prevention of diabetes complications.
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The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes.
Farzad Shidfar,Asadollah Rajab,Tayebeh Rahideh,Nafiseh Khandouzi,Sharieh Hosseini,Shahrzad Shidfar +5 more
TL;DR: Glycemic indices, total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), serum paraoxonase, dietary intake and physical activity were measured and showed that the differences between the ginger and placebo groups were statistically significant.
189
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