Prevalence of clinically significant red blood cell alloantibodies in pregnant women at a large tertiary-care facility.
TL;DR: The prevalence and specificities of unexpected RBC alloantibodies known to cause HDFN in pregnant women at a tertiary-care facility during a 5-year period were compiled and analyzed.
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Abstract: More than 50 red blood cell (RBC) alloantibodies are known to cause hemolytic disease of the fetus and newborn (HDFN)Although Rh immune globulin (RhiG) prophylaxis has significantly reduced the incidence of pregnancies complicated by anti-D, the need to detect and monitor maternal allo antibodies capable of causing HDFN is still a concern The prevalence and specificity of these alloantibodies were determined In this retrospective study, the prevalence and specificities of unexpected RBC alloantibodies known to cause HDFN in pregnant women at a tertiary-care facility during a 5-year period were compiled and analyzed Patient selection was carried out by computerized search of patient data based on an obstetric location and the presence or history of RBC antibody between January 1, 2007,and December 31, 2011 The information was organized by ABO and D status of the patient, antibody specificity, and transfusion needs Of the 8894 obstetric patients identified during the 5-year period, 264 (30%) had one or more unexpected RBC antibodiesOf these 264 women, 107 (405%), or 12 percent overall, had an alloantibody known to cause HDFN, with a total of 15 different alloantibodies identified The most common alloantibody found was anti-E (n = 33), followed by anti-M (n = 26) and anti-D (n= 20) In pregnancies of D- women, the most common clinically significant antibodies found were anti-D (n = 20), anti-C (n = 11),and anti-E (n = 2) In pregnancies of D+ women, the most common antibodies were anti-E (n = 31), anti-M (n = 25), and anti-K (n= 16) A total of eight pregnancies with alloantibodies required intrauterine transfusions with the specificities of anti-D; anti-D,-C(n = 2); anti-D,-C,-E; anti-D,-C,-K; anti-D,-C,-Jkb; anti-D,-S; and anti-E,-c At a large academic tertiary-care center, approximately 1 in 83 obstetric patients had one or more RBC alloantibodies capable of causing HDFN Anti-E, -M, and -D were the most frequent specificities, respectively
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Guideline for blood grouping and red cell antibody testing in pregnancy
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Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) database.
Matthew S. Karafin,Matt Westlake,Ronald G. Hauser,Christopher A. Tormey,Philip J. Norris,Philip J. Norris,Nareg Roubinian,Nareg Roubinian,Yanyun Wu,Darrell J. Triulzi,Steve Kleinman,Jeanne E. Hendrickson,Nhlbi Recipient Epidemiology,Donor Evaluation Study-III +13 more
TL;DR: Data collected in this multi‐centre recipient database provide the largest RBC alloimmunized patient cohort studied in the US, with previously known demographic and disease associations of responder status confirmed, and new associations identified.
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Anti-M Alloimmunization: Management and Outcome at a Single Institution.
TL;DR: The incidence of severe hemolytic disease of the newborn due to anti-M is extremely low, and an algorithm for the management ofAnti-M antibodies in pregnancy is created based on data and extensive literature review.
Live birth prevalence of hemolytic disease of the fetus and newborn in the United States from 1996 to 2010
TL;DR: In this article , the authors used data from the 1996 to 2010 National Hospital Discharge Survey to identify live births, defined by inpatient visits with the newborn flag, with and without a diagnosis of HDFN across 200 to 500 sampled hospitals (≥6 beds) per year.
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