Prevalence and spectrum of electroencephalogram-identified epileptiform activity among patients with long QT syndrome.

TL;DR: Evidence for the mechanisms that cause cardiac, respiratory and arousal abnormalities during the ictal and postictal period is summarized and potential cellular mechanisms underlying these abnormalities are highlighted, such as a defect in the serotonergic system, ICTal adenosine release, and changes in autonomic output.

TL;DR: The fascinating borderland of epilepsy and cardiovascular conditions is discussed, focusing on epidemiology, clinical presentations and possible mechanisms for shared pathophysiology, and a call for validated screening instruments and guidelines aiding the early identification and treatment of CV comorbidity in epilepsy.

TL;DR: Neuroimaging and molecular genetic studies may provide insights into the causes of SUDEP and identify potential biomarkers for risk stratification of patients susceptible to SUDEP.

TL;DR: A mounting body of evidence is highlighted for the involvement of genetic risk factors in SUDEP, including respiratory dysfunction, cardiac arrhythmia and postictal generalized electroencephlogram suppression.

TL;DR: In this article, positional cloning was used to establish KVLQT1 as the chromosome 11-linked LQT 1 gene responsible for the most common inherited cardiac arrhythmia.

TL;DR: Genetic linkage between LQT3 and polymorphisms within SCN5A, the cardiac sodium channel gene, and single strand conformation polymorphism and DNA sequence analyses suggest that mutations in SCN 5A cause chromosome 3-linked LQt and indicate a likely cellular mechanism for this disorder.

TL;DR: Three deaf-mute children all suffered attacks of fainting, probably Adams-Stokes seizures caused by standstill of the heart, and 3 of the children died in such attacks at the ages of 4, 5, and 9 years, respectively.

TL;DR: The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which is the gene product involved in chromosome 7-associated long QT syndrome (LQTS), an inherited disorder associated with a markedly increased risk of ventricular arrhythmias and sudden cardiac death.