Pregabalin in neuropathic pain: evidences and possible mechanisms
TL;DR: Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions and presents itself as a first line therapeutic agent with remarkable safety and efficacy.
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Abstract: Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the symptoms of various types of neuropathic pain and presents itself as a first line therapeutic agent with remarkable safety and efficacy. Preclinical studies in various animal models of neuropathic pain have shown its effectiveness in treating the symptoms like allodynia and hyperalgesia. Clinical studies in different age groups and in different types of neuropathic pain (peripheral diabetic neuropathy, fibromyalgia, post-herpetic neuralgia, cancer chemotherapy-induced neuropathic pain) have projected it as the most effective agent either as monotherapy or in combined regimens in terms of cost effectiveness, tolerability and overall improvement in neuropathic pain states. Preclinical studies employing pregabalin in different neuropathic pain models have explored various molecular targets and the signaling systems including Ca2+ channel-mediated neurotransmitter release, activation of excitatory amino acid transporters (EAATs), potassium channels and inhibition of pathways involving inflammatory mediators. The present review summarizes the important aspects of pregabalin as analgesic in preclinical and clinical studies as well as focuses on the possible mechanisms.
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Diabetic neuropathic pain: Physiopathology and treatment.
Anne K. Schreiber,Carina Fm Nones,Renata Cristiane dos Reis,Juliana Geremias Chichorro,Joice Maria da Cunha +4 more
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Central sensitization in chronic low back pain: A narrative review
Ilaria Sanzarello,Luciano Merlini,Michele Attilio Rosa,Mariada Perrone,Jacopo Frugiuele,Raffaele Borghi,Cesare Faldini +6 more
TL;DR: The purposes of this narrative review are to describe central sensitization and its symptoms and signs in patients with chronic pain disorders in order to allow its recognition in Patients with nonspecific low back pain.
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Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.
TL;DR: Pregabalin has beneficial effects on some symptoms of neuropathic pain, however, its use significantly increases the risk of a number of adverse events and discontinuation due to adverse events.
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