Journal Article10.1016/0165-4608(81)90066-2
Preferential involvement of chromosome 1q in a primary breast carcinoma
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TL;DR: The cytogenetic findings by G- and C-banding in a primary breast carcinoma are reported, supporting the hypothesis that duplication of chromosome 1q may play an important role in the progression of malignant tumors.
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About: This article is published in Cancer Genetics and Cytogenetics. The article was published on 01 Mar 1981. The article focuses on the topics: Breast carcinoma & Chromosome.
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Citations
Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment
TL;DR: A cDNA clone, designated CaN19 (originally called clone 19), isolated by subtractive hybridization, contains sequences that are preferentially expressed in normal mammary epithelial cells but not in breast tumor cells, suggesting that its regulation is calcium-dependent.
173
The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients.
TL;DR: The isolation and characterization of differentiating human epithelial cell lines at different stages in malignant transformation provide an opportunity to examine the cellular and molecular mechanisms controlling tumour progression in the large intestine, and to obtain an insight into the multistep process of human epithel carcinogenesis.
143
Breast cancer genetic evolution: I. Data from cytogenetics and DNA content.
Bernard Dutrillaux,Michèle Gerbault-Seureau,Yorgos Remvikos,Brigitte Zafrani,Marguerite Prieur +4 more
TL;DR: It is shown that the increase of chromosome number and DNA index above diploidy is very limited, and that all tumors with more than 50 chromosomes and 1.35 DNA content passed through endoreduplication results in many possible losses of heterozygosity in these cases.
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Cytogenetic analysis in human breast carcinoma. I. Nine cases in the diploid range investigated using direct preparations.
TL;DR: The only chromosome feature common to all nine breast carcinomas was the presence of a marker involving the long arm of chromosome #1, the region shared by all being 1qter----1q21.
125
The chromosomal analysis of human solid tumors a triple challenge
TL;DR: The present review considers the three main issues of the cytogenetic analysis of human solid tumors: the technical limitations, the difficulty in interpreting the available results, and the uncertainty affecting any hypothesis about the role of chromosome changes in tumorigenesis.
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References
Chromosomes 1 in 14 ovarian cancers. Heterochromatin variants and structural changes.
N. B. Atkin,V J Pickthall +1 more
TL;DR: In this article, structural rearrangement of chromosomes 1 was found in 9 out of 14 ovarian carcinomas and may also have been present in three others, and pericentric inversions involving the heterochromatic regions of chromosomes1 were seen, and were also identified in one of the chromosomes 1 in the patient's normal cells (lymphocytes).
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Quinacrine fluorescent karyotypes of human diploid and heteroploid cell lines.
TL;DR: Quinacrine-fluorescence karyotypes were prepared on a series of human cell lines and were indistinguishable from those obtained from cultured XX blood leukocytes.
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