Journal Article10.1111/J.1365-2133.1986.TB02818.X
Precocious appearance of involucrin and epidermal transglutaminase during differentiation of psoriatic skin.
92
TL;DR: The results suggest that the integrated control of several independent pathways of terminal differentiation is lost in psoriasis, resulting in the classical feature of parakeratosis with absence of the stratum granulosum.
read more
Abstract: SUMMARY
We compared the distribution in psoriatic skin of three different markers usually found in the stratum granulosum of normal skin. Using dansylcadaverine, we demonstrate that epidermal transglutaminase activity can be detected in most of the suprabasal layers of involved psoriatic skin and that the epidermal transglutaminase activity closely matches involucrin distribution. The glycoprotein GP37 was not detected in involved psoriatic skin of stable lesions. These results suggest that the integrated control of several independent pathways of terminal differentiation is lost in psoriasis, resulting in the classical feature of parakeratosis with absence of the stratum granulosum.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis
Gys J. de Jongh,Patrick L.J.M. Zeeuwen,M. Kucharekova,Rolph Pfundt,Pieter G. M. Van Der Valk,Willeke A. M. Blokx,Aynur Dogan,Pieter S. Hiemstra,Peter C.M. van de Kerkhof,Joost Schalkwijk +9 more
TL;DR: It is concluded that psoriatic epidermis expresses high levels of host defense proteins compared with atopic dermatitisEpidermis, and this phenomenon appears to be specific for these proteins.
298
Keratin and keratinization
TL;DR: A flood of new knowledge and discoveries in the basic science of keratins and keratinization has appeared in the past several years, with a focus on the epithelial keratin polypeptides, keratin intermediate filaments, keratohyaline granule proteins, cell envelope formation and cell envelope proteins.
263
•Journal Article
Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development
Laura A. Hansen,Natalie Alexander,Margaret E. Hogan,John P. Sundberg,Andrzej A. Dlugosz,David W. Threadgill,Terry Magnuson,Stuart H. Yuspa +7 more
TL;DR: Ethelial expression of the EGFR is important in delaying follicular differentiation, may serve to protect the hair follicle from immunological reactions, and modifies both normal and wound-induced epidermal proliferation but seems dispensable for follicular proliferation.
235
Ultrastructural localization of calcium in psoriatic and normal human epidermis.
TL;DR: All psoriatic suprabasal cell layers displayed heavier than normal concentrations of calcium, indicating loss of the normal calcium gradient that programs terminal differentiation, which may account for the differentiation defects that occur in psoriasis.
204
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.
TL;DR: This work demonstrates that keratinocyte TJs form a barrier for Na(+), Cl(-), and Ca(2+), and contribute to barrier function for water and larger molecules of different size, and discriminate TJ-dependent paracellular resistance from transcellular resistance in cultured keratinocytes using the two-path impedance spectroscopy.
177
References
Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies.
TL;DR: Three monoclonal antibodies (AE1, AE2, and AE3) were prepared against human epidermal keratins and used to study keratin expression during normalEpidermal differentiation, showing that certain keratin antigens must be masked in situ by direct analysis of ker atins extracted from serial, horizontal skin sections using the immunoblot technique.
799
Keratinocyte-specific transglutaminase of cultured human epidermal cells: Relation to cross-linked envelope formation and terminal differentiation
Scott M. Thacher,Robert H. Rice +1 more
TL;DR: Observations support the hypothesis that the transglutaminase identified in cultured normal human epidermal keratinocytes is involved in cross-linked envelope formation in vivo.
495
Protein modifications during the keratinization of normal and psoriatic human epidermis
David Skerrow,Irene Hunter +1 more
TL;DR: It is concluded that this is a major, reversible difference between involved psoriatic epidermis and uninvolved psoriatics and that it most probably results from a defect in the synthesis of the alpha-chain.
101
Abnormal maturation pathway of keratinocytes in psoriatic skin.
TL;DR: The results indicate that the alterations in keratinocyte maturation found in psoriasis do not arise from a truncation of the normal maturation pathway but rather reflect the onset of an abnormal pathway of differentiation characterized by the expression of Ψ3 antigen and fibronectin and the premature appearance of involucrin.
68
Epidermal and hair follicle transglutaminases and crosslinking in skin.
TL;DR: Epidermal and hair follicle transglutaminases crosslink structural proteins in the skin by epsilon-(gammaglutamyl)-lysine bonds, which produces protein polymers that are extremely insoluble and, until recently, difficult to characterize.
63