Journal Article10.1016/S0006-2952(02)01445-4
Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption.
Alice Wattel,Saïd Kamel,Romuald Mentaverri,Florence Lorget,Christophe Prouillet,Jean-Pierre Petit,Patrice Fardelonne,Michel Brazier +7 more
222
TL;DR: It is demonstrated that flavonols widely distributed in human diet such as quercetin and kaempferol, exert a potent inhibitory effect on in vitro bone resorption.
read more
About: This article is published in Biochemical Pharmacology. The article was published on 01 Jan 2003. The article focuses on the topics: Kaempferol & Bone resorption.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A review on the dietary flavonoid kaempferol.
José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Concepción Pérez-Guerrero,Miguel López-Lázaro +3 more
TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
1.2K
A comparison of hipfracture incidence among native Japanese, Japanese Amemricans, and American caucasians
P. D. Ross
- 01 Jan 1991
TL;DR: Although diet and other cultural attributes of the Oahu group have become more westernized than the Okinawan population, there were no detectable differences in hip fracture rates between Oahu and Okinawa Japanese.
241
Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence.
TL;DR: Considering the important contributions of quercetin in regulating bone homeostasis, it may be considered an economical and promising agent for improving bone health.
The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss.
Tae-Ho Kim,Ji Won Jung,Byung Geun Ha,Jung Min Hong,Eui Kyun Park,Eui Kyun Park,Hyun-Ju Kim,Shin-Yoon Kim,Shin-Yoon Kim +8 more
TL;DR: The data strongly suggest that luteolin has the potential for prevention of bone loss in postmenopausal osteoporosis by reducing both osteoclast differentiation and function.
154
The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies.
TL;DR: Kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.
References
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
TL;DR: The role and the molecular mechanism of action of regulatory molecules, such as cytokines and hormones, in osteoclast and osteoblast birth and apoptosis are reviewed to review the evidence for the contribution of changes in bone cell birth or death to the pathogenesis of the most common forms of osteoporosis.
Flavonoids as antioxidants: determination of radical-scavenging efficiencies.
TL;DR: The radical chemistry of flavonoids not only is of interest from a kinetic or mechanistic point of view but also offers considerable insight into structural relationships of highly evolved plant components.
1.7K
Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis
TL;DR: Changes in the numbers of bone cells, rather than changes in the activity of individual cells, form the pathogenetic basis of osteoporosis is a major advance in understanding the mechanism of this disease.
1.7K
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
TL;DR: The content of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricet in, apigenin, and luteolin of 28 vegetables and 9 fruits was determined by RP-HPLC with UVdetection.
1.4K