Population Control: Cortical Interneurons Modulate Oligodendrogenesis
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TL;DR: This issue of Neuron shows how cortical interneurons modulate oligodendrogenesis through a cytokine-mediated paracrine interaction.
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About: This article is published in Neuron. The article was published on 03 May 2017. and is currently open access. The article focuses on the topics: Neuron.
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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Esther Rheinbay,Shawn M. Gillespie,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Andrew S. Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,David N. Louis,Bradley E. Bernstein,Aviv Regev +23 more
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TL;DR: This study identifies a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, and OLIG2) essential for GBM propagation and reconstructs a network model that highlights critical interactions and identifies candidate therapeutic targets for eliminating TPCs.
References
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.
Nicoletta Kessaris,Matthew Fogarty,Palma Iannarelli,Matthew Grist,Michael Wegner,William D. Richardson +5 more
TL;DR: It is shown, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain, and that functionally redundant populations of OLPs compete for space in the developing brain.
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Anoop P. Patel,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Nicolo Riggi,Anthony Wei Shine Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Miguel Rivera,Nikki E. Rossetti,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,David N. Louis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +37 more
TL;DR: In this paper, a core set of neurodevelopmental transcription factors (POU3F2, SOX2, SALL2, and OLIG2) are identified as essential for GBM propagation.
847
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
Humsa S. Venkatesh,Tessa Johung,Viola Caretti,Alyssa Noll,Yujie Tang,Surya Nagaraja,Erin M. Gibson,Christopher Mount,Jai S. Polepalli,Siddhartha Mitra,Pamelyn Woo,Robert C. Malenka,Hannes Vogel,Markus Bredel,Parag Mallick,Michelle Monje +15 more
TL;DR: Findings indicate the important role of active neurons in the brain tumor microenvironment and identify secreted NLGN3 as an unexpected mechanism promoting neuronal activity-regulated cancer growth.
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Inefficient clearance of myelin debris by microglia impairs remyelinating processes
Antoine Lampron,Antoine Larochelle,Nathalie Laflamme,Paul Préfontaine,Marie-Michèle Plante,Maria Gabriela Sánchez,V. Wee Yong,Peter K. Stys,Marie-Ève Tremblay,Serge Rivest +9 more
TL;DR: In CX3CR1-deficient mice, the clearance of myelin debris by microglia is impaired, affecting the integrity of axon and myelin sheaths, a model of demyelination/remyelination.
Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
Yang Yu,Yang Yu,Ying Chen,Bong-Woo Kim,Bong-Woo Kim,Haibo Wang,Chuntao Zhao,Xuelian He,Xuelian He,Lei Liu,Lei Liu,Wei Liu,Wei Liu,Lai Man N. Wu,Meng Mao,Jonah R. Chan,Jiang Wu,Q. Richard Lu +17 more
TL;DR: Regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS.
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