PopED lite

TL;DR: In this article, a PBPK model incorporating saturable target binding and hepatic uptake was developed to predict target occupancy in clinical bosentan using the cluster Gauss-Newton method (CGNM).

TL;DR: A novel Dibenzyl (benzo[d]thiazol-2-yl(hydroxy)methyl) phosphonate derived from α-Hydroxyphosphonate exhibited anti-Staphylococcus aureus and anti-biofilm properties against penicillin, ampicillin and methicillin-resistant strains of S. aureu.

TL;DR: The authors present una revision del estado actual de las tecnologias que estan revolucionando la atencion medica a nivel mundial, realizando un analisis de su utilidad actual y hacia donde se dirige la atención medica in el future, realizing reflexiones sobre las innovaciones y transformaciones that constantemente se producen and que ocasionaran cambios in los enfoques medicos dando origen a la medicina tras

TL;DR: This study investigates the population pharmacokinetics of enrofloxacin and florfenicol in giant danio, a freshwater ornamental fish, following oral and bath administration, providing guidance on effective antibiotic dosing and target attainment for bacterial pathogens.

TL;DR: A ground detecting device for a vehicle, craft, or the like, having a storage tank mounted on the vehicle, orthe like, equipment for selectively controlling the pumping of fluid into and out of the storage tank, comprises a transformer having first, second and third windings, the third winding being electrically connected to ground.

TL;DR: In this article, the authors present an analysis of experiments with both qualitative and quantitative factors: Blocking response surface designs, restricted region designs, failure of the experiment and design augmentation, and discrimination between models.

TL;DR: This revised and expanded edition includes a CD with all exercises and WinNonlin model/ command files and raises the stature of PK/PD modeling to its highest level.