Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study.
Yeyi Zhu,Yeyi Zhu,Monique M. Hedderson,Sneha B. Sridhar,Fei Xu,Juanran Feng,Assiamira Ferrara +6 more
31
TL;DR: Poor diet quality in pregnancy was associated with higher birthweight and increased risk of LGA independent of maternal obesity and other covariates, and substitution of empty calories with whole grains may mitigate the risk of excess fetal growth.
read more
Abstract: BACKGROUND Nutritional perturbations during pregnancy may impact fetal and long-term childhood growth, although there are limited data on overall diet quality. We investigated whether diet quality, measured by the Healthy Eating Index-2010 (HEI-2010), during pregnancy was related to birthweight z-score (BWZ) and the clinically relevant birth outcomes of large- and small-for-gestational age (LGA and SGA). METHODS In a prospective cohort of 2269 multi-racial/ethnic women from the Pregnancy Environment and Lifestyle Study (2014-2017), dietary intake was assessed by a food frequency questionnaire during early pregnancy. Offspring BWZ and LGA or SGA were derived based on gestational age-, sex-, and racial/ethnic-specific birthweight distributions. Multivariable linear and Poisson regression with robust standard errors were used. RESULTS About 80% of women did not achieve good diet quality (HEI-2010 < 80). After adjusting for covariates, infants born to women in the lowest vs highest quartile of HEI-2010 (37.5-64.4 vs 78.7-94.2) had a 0.12 standard-deviation [95% confidence interval (CI) 0.01-0.23, P-for-trend = 0.023] greater BWZ and 1.76-fold (1.08-2.87, P-for-trend = 0.037) increased risk of LGA. No association was observed between HEI-2010 and SGA. Per-5-point substitution of the reversely coded empty calories component score with the whole grains component score in the HEI-2010 was related to a 25% (95% CI 0.66-0.86) lower risk of LGA. CONCLUSIONS Poor diet quality in pregnancy was associated with higher birthweight and increased risk of LGA independent of maternal obesity and other covariates. Substitution of empty calories with whole grains may mitigate the risk of excess fetal growth. Our findings may inform potential prevention strategies and dietary guidelines for pregnant women.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Associations between Maternal Dietary Patterns and Perinatal Outcomes: A Systematic Review and Meta-Analysis of Cohort Studies.
Shima Abdollahi,Sepideh Soltani,Russell J. de Souza,Russell J. de Souza,Scott C. Forbes,Omid Toupchian,Amin Salehi-Abargouei +6 more
TL;DR: In this paper, a systematic review and meta-analysis of prospective cohort studies investigating the relation between maternal dietary patterns during pregnancy with pregnancy and birth outcomes was conducted, and the results showed that a higher maternal adherence to a healthy diet was associated with a reduced risk of gestational hypertension.
59
Assessing the Economic Feasibility of Assuring Nutritionally Adequate Diets for Vulnerable Populations in Uttar Pradesh, India: Findings from a "Cost of the Diet" Analysis.
Shivani Kachwaha,Phuong H. Nguyen,Michelle DeFreese,Rasmi Avula,Shruthi Cyriac,Amy Webb Girard,Purnima Menon +6 more
- 01 Jun 2019
TL;DR: Foods available in local market are sufficient for households to obtain recommended intakes of macro- and micronutrients and additional social protection for poorer households could improve optimal nutrient intakes.
Associations between pre-pregnancy BMI, gestational weight gain, and prenatal diet quality in a national sample.
TL;DR: Interventions to broadly improve prenatal diet quality are needed, however, resources can be used to target women with higher pre-pregnancy BMIs and women with inadequate or excessive gestational weight gain.
Maternal Dietary Quality and Dietary Inflammation Associations with Offspring Growth, Placental Development, and DNA Methylation.
TL;DR: In this article, the authors examine the current literature regarding relationships between key validated diet quality scores (Dietary Inflammatory Index [DII], Mediterranean diet [MD], healthy eating index [HEI], Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension [DASH], Glycaemic Index [GI] and Glycaemia Load [GL]) in pregnancy and birth and long-term offspring outcomes.
29
Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to a diet rich in high fat and branched-chain amino acids.
Marianna Sadagurski,Lucas Kniess Debarba,Joao Pedro Werneck-de-Castro,Abear Ali Awada,Tess A. Baker,Ernesto Bernal-Mizrachi,Ernesto Bernal-Mizrachi +6 more
TL;DR: The sex differences in hypothalamic ER-α expression levels were lost in female offspring upon HFD challenge, supporting a link between ER- α levels and hypothalamic inflammation in offspring and highlighting the programming potential of hypothalamic inflammatory responses and maternal nutrition.
16
References
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Adjustment for total energy intake in epidemiologic studies
TL;DR: Several disease-risk models and formulations of these models are available to account for energy intake in epidemiologic analyses, including adjustment of nutrient intakes for total energy intake by regression analysis and addition of total energy to a model with the nutrient density.
3.5K
Total energy intake: implications for epidemiologic analyses
TL;DR: While pitfalls in the manipulation and interpretation of energy intake data in epidemiologic studies have been emphasized, these considerations also highlight the usefulness of obtaining a measurement of total caloric intake, which is not accomplished with nutrient density measures of dietary intake.
2.9K
Criteria for screening tests for gestational diabetes
TL;DR: Test results suggest that thresholds for further testing be lowered from 143 to 135 mg/dl of plasma glucose, where further testing is required.
1.9K
The Healthy Eating Index: design and applications.
TL;DR: The HEI is a useful index of overall diet quality of the consumer and will be used by the US Department of Agriculture to monitor changes in dietary intake over time and as the basis of nutrition promotion activities for the population.
1.7K
Related Papers (5)
Kayo Kaneko,Yuki Ito,Takeshi Ebara,Sayaka Kato,Taro Matsuki,Hazuki Tamada,Hirotaka Sato,Shinji Saitoh,Mayumi Sugiura-Ogasawara,Shin Yamazaki,Yukihiro Ohya,Reiko Kishi,Nobuo Yaegashi,Koichi Hashimoto,Chisato Mori,Shuichi Ito,Zentaro Yamagata,Hidekuni Inadera,Takeo Nakayama,Hiroyasu Iso,Masayuki Shima,Youichi Kurozawa,Narufumi Suganuma,Koichi Kusuhara,Takahiko Katoh,Michihiro Kamijima +25 more