Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis.
Liv B. Gansmo,Benedicte A. Lie,Marthe T. Maehlen,Lars J. Vatten,Pål Richard Romundstad,Kristian Hveem,Per Eystein Lønning,Stian Knappskog,Stian Knappskog +8 more
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TL;DR: In this article, the potential impact of these variants on risk of rheumatoid arthritis (RA) was assessed using GWAS-data, and they found that individuals with the del158-285-309 genotype del/ins-G/G-T/T had an increased risk of RA as compared to those with the g/g/G/T genotype.
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About: This article is published in Gene. The article was published on 30 May 2021. and is currently open access. The article focuses on the topics: Genotype & Haplotype.
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Genetics of rheumatoid arthritis contributes to biology and drug discovery
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TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.