Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of drosophila melanogaster
TL;DR: The results of clonal analysis experiments indicate that, at least for the BX-C, Pcl+ exerts this control until late in development, and arguments are presented that the control of the Bx-C and ANT-C by Pcl- is negative in nature.
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Abstract: A newly identified gene is described that is required for the maintenance of normal identities in many of the body segments of the fly. The effects of mutants in this gene, which is called Polycomblike (Pcl), suggest that its wild-type allele functions in the regulation of the bithorax gene complex (BX-C) and the Antennapedia gene complex (ANT-C). Evidence in favor of this idea derives from (1) the close correspondence between segmental transformations caused by Pcl mutants and those caused by dominant gain-of-function mutants in the BX-C and ANT-C, (2) the interactions observed between Pcl mutants and mutants in these complexes, and (3) the dependence upon BX-C and ANT-C dosage of the severity of at least one of the transformations caused by Pcl mutants. Arguments are presented that the control of the BX-C and ANT-C by Pcl+ is negative in nature. The results of clonal analysis experiments indicate that, at least for the BX-C, Pcl+ exerts this control until late in development. Since the wild-type allele of another gene, called Polycomb (Pc), has previously been shown to have many of the same properties as Pcl+, it appears that the BX-C and perhaps also the ANT-C are continuously regulated during development by at least two and probably several other genes.
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Citations
staufen, a gene required to localize maternal RNAs in the Drosophila egg
TL;DR: It is shown that staufen protein is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with oskar RNA.
668
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
James A. Kennison,John W. Tamkun +1 more
TL;DR: Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia and four additional loci identified here have also been shown to have homoeotic phenotypes.
512
Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
TL;DR: This work focuses on the dynamics of PcG protein complex action during cell fate transitions and on the implications of histone modifications for cell lineage commitment.
458
A group of genes controlling the spatial expression of the bithorax complex in Drosophila
TL;DR: In this article, mutations in four other trans-regulatory genes, members of a novel class of more than 20 genes controlling the spatial expression of Bithorax complex (BX-C) genes are reported.
450
The Trithorax-like gene encodes the Drosophila GAGA factor
Gabriella Farkas,János Gausz,Mireille Galloni,Mireille Galloni,Gunter Reuter,Henrik Gyurkovics,François Karch +6 more
TL;DR: The genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions, and the Trithorax-like gene described here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation.
438
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Ginés Morata,Stephen Kerridge +1 more
TL;DR: Two unexpected results are described: deficiencies for bithorax genes can lead to segments being transformed into prothorax, and there is a temporal sequence in the function of the bithOrax system.
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Developmental studies of lethality associated with the Antennapedia gene complex in Drosophila melanogaster
TL;DR: Transplantation of eye-antennal disks from lethal individuals heterozygous for two different AntpNs revertant chromosomes into wild-type hosts allowed the assessment of the function of the Antp+ allele in the antenna, suggesting that regulatory mechanisms associated with theAntp+ structural gene normally function both to allow its expression in the thorax and to repress it in the antennas.
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