Journal Article10.1016/S0140-6736(89)92631-7
Plasma endothelin levels in patients with uraemia.
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TL;DR: Plasma immunoreactive endothelin concentrations were measured in patients with uraemia and in non-uraemic controls and were beneath the detection limit of the assay in most patients withoutUraemia but were readily detectable in those undergoing haemodialysis.
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About: This article is published in The Lancet. The article was published on 06 May 1989. The article focuses on the topics: Dialysis & Endothelin receptor.
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Citations
Regulatory functions of the vascular endothelium.
TL;DR: The vascular endothelium, which envelops the circulating blood in a continuous monolayer, is mainly responsible for this function, but over the past 20 years numerous other important functions have been discovered.
2K
Endothelin in human congestive heart failure.
Chi Ming Wei,Amir Lerman,Richard J. Rodeheffer,Christopher G.A. McGregor,Roland R. Brandt,R. Scott Wright,Denise M. Heublein,Pai C. Kao,William D. Edwards,John C. Burnett +9 more
TL;DR: The present study establishes for the first time that the elevation of plasma ET in severe human CHF represents principally elevation of big-ET, characteristic of severe CHF and not asymptomatic or mild CHF.
622
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.
TL;DR: Vascular smooth muscle cells of human IMA, IMV, and PCA contain both ETA and ETB receptors, whereas the endothelium of IMA andPCA does not express functional ETB receptor linked to nitric oxide and/or prostacyclin production, and inhibition of endothelin-induced contraction in patients requires the use of combined ETA/ETB antagonists.
546
Elevated plasma endothelin in patients with diabetes mellitus.
TL;DR: The elevation of immunoreactive-endothelin in diabetic patients may be a marker of, and further exacerbate, their vascular disease.
Endothelium-derived contracting factors.
TL;DR: Vascular endothelin production in hypertension remains controversial but appears mostly normal; it is augmented in the presence of vascular disease or renal insufficiency and the reactivity of vascular smooth muscle may be normal, increased, or reduced.
407
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
TL;DR: NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator.
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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The role of endothelium in the responses of vascular smooth muscle to drugs
TL;DR: A number of laboratories are now engaged in research on various aspects of the endothelium-dependent relaxation of blood vessels by various agents, and this review attempts to bring together the more important findings in this new area of research.
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