Physicians' Beliefs About the Benefits and Risks of Adjuvant Therapies for Stage II and Stage III Colorectal Cancer
Anthony C. Wong,Shannon Stock,Deborah Schrag,Katherine L. Kahn,Talya Salz,Mary E. Charlton,Selwyn O. Rogers,Karyn A. Goodman,Nancy L. Keating +8 more
TL;DR: Physicians largely agreed that the benefits of adjuvant chemotherapy for stage III colon cancer, as well as chemotherapy, and radiation for stageIII rectal cancer, outweigh the risks, consistent with strong evidence, but were divided over the net benefit of adjUvant therapies for stage II colorectal cancer.
read more
Abstract: Physicians agreed that the benefits of adjuvant chemotherapy for stage III colon cancer and chemotherapy, and radiation for stage III rectal cancer, outweigh the risks, but were divided over the net benefit of adjuvant therapies for stage II colorectal cancer.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Influential factors on treatment decision making among patients with colorectal cancer: A scoping review
TL;DR: Evaluating factors that are influential in treatment decision-making among patients with CRC found that patients wanted to be informed and involved but did not necessarily want to make autonomous treatment choices, with many preferring a more passive role.
18
A novel prognostic prediction model for recurrence in patients with stage II colon cancer after curative resection.
Kazuhiro Saso,Norikatsu Myoshi,Shiki Fujino,Yuya Takenaka,Yusuke Takahashi,Junichi Nishimura,Masayoshi Yasui,Masayuki Ohue,Masayoshi Tokuoka,Yoshihito Ide,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Tsunekazu Mizushima,Yuichiro Doki,Masaki Mori +16 more
TL;DR: A novel, reliable and personalized prognostic model was developed to predict recurrence in patients with stage II colon cancer, which may help clinicians to determine and perform adjuvant chemotherapy.
Prognostic Factors and the Role of Adjuvant Chemotherapy in Post-curative Surgery for Dukes B and C Colon Cancers and Survival Outcomes: a Malaysian Experience
TL;DR: In a regional context, this study supports current evidence from the West that adjuvant chemotherapy improves survival in Dukes C colon cancers post curative surgery and suggests survival improvement in selected cases.
The Role of Adjuvant Treatment in Resected T3N0 Rectal Cancer
TL;DR: The evidence for adjuvant chemotherapy in this setting is reviewed and clinico-pathologic variables that may be useful for making a decision in favor of offering adjUvant therapy or observation are set out.
2
Is There a Role for Adjuvant Chemotherapy in Rectal Cancer
TL;DR: The role of fluoropyrimidine-based and oxaliplatin-based adjuvant chemotherapy in patients treated with neoadjuvant chemoradiotherapy is discussed.
1
References
•Book
Statistical Analysis with Missing Data
Roderick J. A. Little,Donald B. Rubin +1 more
- 01 Jan 1987
TL;DR: This work states that maximum Likelihood for General Patterns of Missing Data: Introduction and Theory with Ignorable Nonresponse and large-Sample Inference Based on Maximum Likelihood Estimates is likely to be high.
18.3K
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
Rolf Sauer,Heinz Becker,Werner Hohenberger,Claus Rödel,Christian Wittekind,Rainer Fietkau,Peter Martus,Jörg Tschmelitsch,Eva Hager,Clemens F. Hess,Torsten Liersch,Heinz Schmidberger,Rudolf Raab +12 more
TL;DR: Preoperative chemoradiotherapy, as compared with postoperative cheMoradi therapy, improved local control and was associated with reduced toxicity but did not improve overall survival.
6K
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Ellen Kapiteijn,Corrie A.M. Marijnen,Iris D. Nagtegaal,Hein Putter,W.H. Steup,Theo Wiggers,Harm J. T. Rutten,Lars Påhlman,Bengt Glimelius,J. Han van Krieken,J.W.H. Leer,Cornelis J.H. van de Velde +11 more
TL;DR: In this article, the authors conducted a multicenter, randomized trial to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision, and the overall rate of survival at two years among the eligible patients was 82.0 percent in the group assigned to both radiotherapy and surgery.
Chemotherapy with preoperative radiotherapy in rectal cancer
Jean-François Bosset,Laurence Collette,Gilles Calais,Laurent Mineur,Philippe Maingon,L. Radosevic-Jelic,Alain Daban,Etienne Bardet,Alexander Beny,Jean-Claude Ollier +9 more
TL;DR: In patients with rectal cancer who receive preoperative radiotherapy, adding fluorouracil-based chemotherapy preoperatively or postoperatively has no significant effect on survival.
2.6K