Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography
TL;DR: The role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases is summarized.
read more
Abstract: Spectral domain optical coherence tomography cross-sectional imaging of the macula has conventionally been resolved into four bands. However, some doubts were raised regarding authentication of the existence of these bands. Recently, a number of studies have suggested that the second band appeared to originate from the inner segment ellipsoids of the foveal cone photoreceptors, and therefore the previously called inner segment-outer segment junction is now referred to as inner segment ellipsoidband. Photoreceptor dysfunction may be a significant predictor of visual acuity in a spectrum of surgical and medical retinal diseases. This review aims to provide an overview and summarizes the role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial
M. Dominik Fischer,G. Alex Ochakovski,Benjamin Beier,Immanuel P. Seitz,Yousof Vaheb,Constanze Kortuem,Felix F L Reichel,Laura Kuehlewein,Nadine Kahle,Tobias Peters,Aniz Girach,Eberhart Zrenner,Marius Ueffing,Robert E MacLaren,Karl Ulrich Bartz-Schmidt,Barbara Wilhelm +15 more
TL;DR: Among 6 participants, gene therapy with AAV2-REP1 was associated with maintenance or improvement of visual acuity, although no significant difference was found from control eyes, and continued investigations could more precisely define the efficacy and safety of gene therapy in CHM.
Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.
Vijayendran Chandran,Kun Gao,Vivek Swarup,Revital Versano,Hongmei Dong,Maria C. Jordan,Daniel H. Geschwind +6 more
TL;DR: An inducible mouse model of Fxn deficiency was developed that enabled us to control the onset and progression of disease phenotypes by the modulation of FXn levels, and observed significant recovery of function, associated pathology and transcriptomic dysregulation even after substantial motor dysfunction and pathology were observed.
77
•Journal Article
Outer Retina Analysis by Optical Coherence Tomography in Cone-Rod Dystrophy Patients
TL;DR: SD-OCT scans demonstrated complete absence of the interdigitation zone in patients with cone-rod dystrophy, which may represent abnormal outer retinal morphology, including an absent of the outer segments themselves or a defective or absentinterdigitation between the apical processes of the retinal pigment epithelium with the cone outer segments.
40
Interspecies Variation of Outer Retina and Choriocapillaris Imaged With Optical Coherence Tomography.
Petr Soukup,Petr Soukup,Peter Maloca,Peter Maloca,Bernd Altmann,Matthias Festag,Elke-Astrid Atzpodien,Simon A. Pot +7 more
TL;DR: The choriocapillaris is an easy and valid marker for identification of the outer retinal margin and ORB presentation likely varies due to differences in retinal anatomy and pigmentation between animal species and strains and between anatomic locations.
References
Correlation of fundus autofluorescence with spectral-domain optical coherence tomography and vision in diabetic macular edema.
TL;DR: The strong association of FAF with SD-OCT parameters and VA in patients with DME could aid in the prediction of the restoration of photoreceptor integrity and subsequent visual recovery, especially in Patients with severe DME, in whom photorecept integrity before treatment could not be adequately evaluated, even with SD -OCT.
Spectral-domain optical coherence tomography for monitoring epiretinal membrane surgery.
TL;DR: Besides the baseline VA, the integrity of the IS/OS line, better visualized by SD OCT, can be used to predict the functional outcomes after surgery.
The significance of the external limiting membrane in the recovery of photoreceptor layer after successful macular hole closure: a study by spectral domain optical coherence tomography.
TL;DR: The restoration of the IS/OS junction line is directly related to the integrity of the ELM, and improvement in best-corrected visual acuity over follow-up is noted.
Axial length as a factor associated with visual outcome after vitrectomy for diabetic macular edema.
Yoshihiro Wakabayashi,Keisuke Kimura,Daisuke Muramatsu,Yoshihiko Usui,Kazuhiko Umazume,Jun Suzuki,Hiroshi Goto +6 more
TL;DR: Multivariate logistic regression analysis showed that short axial length increased the risk of poor visual outcome after surgery and predicted better postoperative BCVA after vitrectomy for diffuse macular edema secondary to diabetic retinopathy.
Long-term chorioretinal changes after photodynamic therapy for chronic central serous chorioretinopathy
Helena Vasconcelos,Inês Marques,A. Rita Santos,Pedro Melo,Isabel Pires,João Figueira,Jose F. Abreu,M. Luz Cachulo,Rufino Silva +8 more
TL;DR: Morphological and functional chorioretinal changes, observed 5 or more years after standard PDT for chronic CSC, were not correlated with the location of treatment, neither with the progression of visual acuity or with the Location of Treatment, and are more likely to be related to the disease itself than with the treatment provided.