Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography
TL;DR: The role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases is summarized.
read more
Abstract: Spectral domain optical coherence tomography cross-sectional imaging of the macula has conventionally been resolved into four bands. However, some doubts were raised regarding authentication of the existence of these bands. Recently, a number of studies have suggested that the second band appeared to originate from the inner segment ellipsoids of the foveal cone photoreceptors, and therefore the previously called inner segment-outer segment junction is now referred to as inner segment ellipsoidband. Photoreceptor dysfunction may be a significant predictor of visual acuity in a spectrum of surgical and medical retinal diseases. This review aims to provide an overview and summarizes the role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial
M. Dominik Fischer,G. Alex Ochakovski,Benjamin Beier,Immanuel P. Seitz,Yousof Vaheb,Constanze Kortuem,Felix F L Reichel,Laura Kuehlewein,Nadine Kahle,Tobias Peters,Aniz Girach,Eberhart Zrenner,Marius Ueffing,Robert E MacLaren,Karl Ulrich Bartz-Schmidt,Barbara Wilhelm +15 more
TL;DR: Among 6 participants, gene therapy with AAV2-REP1 was associated with maintenance or improvement of visual acuity, although no significant difference was found from control eyes, and continued investigations could more precisely define the efficacy and safety of gene therapy in CHM.
Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.
Vijayendran Chandran,Kun Gao,Vivek Swarup,Revital Versano,Hongmei Dong,Maria C. Jordan,Daniel H. Geschwind +6 more
TL;DR: An inducible mouse model of Fxn deficiency was developed that enabled us to control the onset and progression of disease phenotypes by the modulation of FXn levels, and observed significant recovery of function, associated pathology and transcriptomic dysregulation even after substantial motor dysfunction and pathology were observed.
77
•Journal Article
Outer Retina Analysis by Optical Coherence Tomography in Cone-Rod Dystrophy Patients
TL;DR: SD-OCT scans demonstrated complete absence of the interdigitation zone in patients with cone-rod dystrophy, which may represent abnormal outer retinal morphology, including an absent of the outer segments themselves or a defective or absentinterdigitation between the apical processes of the retinal pigment epithelium with the cone outer segments.
40
Interspecies Variation of Outer Retina and Choriocapillaris Imaged With Optical Coherence Tomography.
Petr Soukup,Petr Soukup,Peter Maloca,Peter Maloca,Bernd Altmann,Matthias Festag,Elke-Astrid Atzpodien,Simon A. Pot +7 more
TL;DR: The choriocapillaris is an easy and valid marker for identification of the outer retinal margin and ORB presentation likely varies due to differences in retinal anatomy and pigmentation between animal species and strains and between anatomic locations.
References
Intravitreal ranibizumab for choroidal neovascularization complicating pathologic myopia.
Franck Lalloum,Eric H Souied,Sylvie Bastuji-Garin,Nathalie Puche,Giuseppe Querques,Agnès Glacet-Bernard,Gabriel Coscas,Gisèle Soubrane,Nicolas Leveziel +8 more
TL;DR: In a series of myopic choroidal neovascularization, intravitreal injections of ranibizumab showed visual acuity improvement and retinal thickness reduction.
74
•Journal Article
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.
TL;DR: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objectiveVisual field loss.
74
High-resolution spectral domain optical coherence tomography features in adult onset foveomacular vitelliform dystrophy
Nathalie Puche,Giuseppe Querques,Nathanael Benhamou,Sarah Tick,Gerard Mimoun,Domenico Martinelli,G. Soubrane,E.H. Souied +7 more
TL;DR: Early changes in adult onset foveomacular vittelliform dystrophy are hypothesised to involve the layer between RPE and the IS/OS interface, first with vitelliform material accumulation beneath the sensory retina, and then withIS/OS alterations, pigments migration towards inner layers and fluid accumulation.
Intravitreal ranibizumab for choroidal neovascularization secondary to pathologic myopia: 12-month results.
TL;DR: The 12-month results of this consecutive series of 23 patients suggests that a small number of injections of intravitreal ranibizumab may be safe and effective for both preventing and restoring visual loss in patients with CNV secondary to PM.
71
Association between integrity of foveal photoreceptor layer and visual outcome in retinal vein occlusion.
TL;DR: In this article, the integrity of foveal photoreceptor layer and initial and final visual acuity after successful resolution of macular oedema (ME) associated with retinal vein occlusion (RVO) were investigated.
68