Journal Article10.1002/CHIN.201647249
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
413
TL;DR: The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step as mentioned in this paper, which can be used for rapidly accessing structurally and stereochemically diverse scaffolds.
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Abstract: The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the involvement of electronically excited states, generated upon absorption of photons. This produces transient reactive intermediates and significantly alters the reactivity of a chemical compound. The input of energy provided by light thus offers a means to produce strained and unique target compounds that cannot be assembled using thermal protocols. This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds. Synthetic designs based on photochemical transformations have the potential to afford complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
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Citations
Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis
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TL;DR: Diverse chemical approaches to synthesize γ-spiro butenolide comprising natural products and their hybrid analogues and their application towards natural product synthesis are discussed.
34
C(sp2)–H functionalization of aldehyde-derived hydrazones via a radical process
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Leptosperols A and B, Two Cinnamoylphloroglucinol-Sesquiterpenoid Hybrids from Leptospermum scoparium: Structural Elucidation and Biomimetic Synthesis.
Ji-Hong Gu,Wen-Jing Wang,Jun-Zi Chen,Jun-Shan Liu,Ni-Ping Li,Min-Jing Cheng,Min-Jing Cheng,Li-Jun Hu,Chuang-Chuang Li,Wen-Cai Ye,Lei Wang +10 more
TL;DR: Compounds 1 and 2 of leptosperols A and B represent the first example of phloroglucinol derivatives biogenetically constructed by a De Mayo reaction and showed significant anti-inflammatory effects in zebrafish acute inflammatory models.
34
8-Mercaptoquinoline as a Ligand for Enhancing the Photocatalytic Activity of Pt(II) Coordination Complexes: Reactions and Mechanistic Insights
Antonio Casado-Sánchez,Mustafa Uygur,Daniel González-Muñoz,Fernando Aguilar-Galindo,José Luis Nova-Fernández,Judith Arranz-Plaza,Sergio Díaz-Tendero,Silvia Cabrera,Olga García Mancheño,José Alemán +9 more
TL;DR: In the different photochemical transformations investigated, such as cross-dehydrogenative coupling, oxidation of arylboronic acids, and asymmetric alkylation of aldehydes, 8-mercaptoquinoline-Pt(II) complex proved to be the most general catalyst.
33
Synthesis of 3-CF2-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones.
Huang Gao,Bei Hu,Wuheng Dong,Xiaoshuang Gao,Lili Jiang,Xiaomin Xie,Zhaoguo Zhang,Zhaoguo Zhang +7 more
- 05 Jul 2017
TL;DR: A general and efficient visible-light-induced CF2 radical-based cascade reaction of o-hydroxyaryl enaminones has been described, which afforded the corresponding functionalized 3-CF2-containing chromones in generally good yields under mild reaction conditions.
33
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