Photobiomodulation CME Part II: Clinical Applications in Dermatology.
Jessica Mineroff,Jalal Maghfour,David D Ozog,Henry W. Lim,Indermeet Kohli,Jared Jagdeo +5 more
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TL;DR: This study explores the clinical applications of photobiomodulation (PBM) in dermatology, highlighting its non-invasive, cost-effective, and safe treatment of various skin conditions, including cancer therapy-induced side effects, alopecia, and acne, with varying effects across skin types and ethnicities.
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Abstract: Photobiomodulation (PBM) is an emerging treatment modality in dermatology with increasing office and home-based use. PBM is the use of various light sources in the red light (620-700 nm) and near-infrared (700-1440 nm) spectrum as a form of light therapy. PBM is often administered through low-level lasers or light-emitting diodes. Studies show that PBM can be used effectively to treat conditions secondary to cancer therapies, alopecia, ulcers, herpes simplex virus, acne, skin rejuvenation, wounds, and scars. PBM offers patients many benefits compared to other treatments. It is noninvasive, cost-effective, convenient for patients, and offers a favorable safety profile. PBM can be used as an alternative or adjuvant to other treatment modalities including pharmacotherapy. It is important for dermatologists to gain a better clinical understanding of PBM for in-office administration and to counsel patients on proper application for home-use devices to best manage safety and expectations as this technology develops. PBM wavelengths can induce varied biological effects in diverse skin types, races, and ethnicities; therefore, it is also important for dermatologists to properly counsel their skin of color patients who undergo PBM treatments. Future clinical trials are necessary to produce standardized recommendations across conditions and skin types.
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Citations
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation
María Luisa Hernández-Bule,J. Naharro-Rodríguez,Stefano Bacci,M. Fernández-Guarino +3 more
TL;DR: A narrative review of articles about photobiomodulation, LED light therapy or low-level laser therapy and their applications on dermatology published over the last 6 years, encompassing research studies, clinical trials, and technological developments underscores the promising role of PBM as a non-invasive therapeutic approach with broad clinical applicability.
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The Effectiveness of 675 nm Wavelength Laser Therapy in the treatment Androgenetic alopecia among Indian patients. (Preprint)
B. S. Chandrashekar,Oliver Clement Lobo,Irene Fusco,Francesca Madeddu,Tiziano Zingoni +4 more
TL;DR: This study evaluates the efficacy of 675-nm laser therapy for treating androgenetic alopecia in Indian patients, showing significant improvements in hair count, density, and thickness after 14 sessions, with a 17% increase in hair count and 13.91% increase in hair thickness.
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Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation
María Luisa Hernández‐Bule,Jorge Naharro-Rodríguez,Giada Magni,Francesca Rossi,Stefano Bacci,M. Fernández‐Guarino +5 more
- 08 Mar 2024
TL;DR: Unlocking the power of light on the skin: PBM is a non-invasive therapeutic approach with broad clinical applicability and promising outcomes.
2
The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review
Zhixin Zhang,Zhiyu Zhang,Peng Liu,Xinmiao Xue,Chi Zhang,Lili Peng,Shen Weidong,Shiming Yang,Fangyuan Wang +8 more
TL;DR: This systematic review of 19 studies (330 screened) investigates photobiomodulation's impact on ion channels in the nervous system, revealing its potential to modulate cell membrane potentials, neurotransmitter synthesis, and channel activity, with anti-inflammatory and neuroregenerative effects.
1
The Effectiveness of 675 nm Wavelength Laser Therapy in the treatment Androgenetic alopecia among Indian patients. (Preprint)
B. S. Chandrashekar,Oliver Clement Lobo,Irene Fusco,Francesca Madeddu,Tiziano Zingoni +4 more
- 24 May 2024
TL;DR: The 675 nm laser therapy is effective in treating androgenetic alopecia in Indian patients, leading to increased hair density and thickness.
References
Low-level light/laser therapy versus photobiomodulation therapy
TL;DR: The field of phototherapy that utilizes low-dose light for clinical therapy was reborn, and much has been learned about the mechanistic basis of this therapy, including a key fact that this application of light to tissues and organisms can elicit both stimulatory and inhibitory responses, depending upon the light parameters used.
Photobiomodulation-Underlying Mechanism and Clinical Applications.
Claudia Dompe,Claudia Dompe,Lisa Moncrieff,Lisa Moncrieff,Jacek Matys,Kinga Grzech-Leśniak,Kinga Grzech-Leśniak,Ievgeniia Kocherova,Artur Bryja,Małgorzata Bruska,Marzena Dominiak,Paul Mozdziak,Tarcio Hiroshi Ishimine Skiba,Jamil Awad Shibli,Ana Angelova Volponi,Bartosz Kempisty,Marta Dyszkiewicz-Konwińska +16 more
TL;DR: The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers’ underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair.
463
Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.
Yehuda Zadik,Praveen R. Arany,Eduardo Rodrigues Fregnani,Paolo Bossi,Héliton Spíndola Antunes,René-Jean Bensadoun,Luiz Alcino Monteiro Gueiros,Alessandra Majorana,Raj G. Nair,Vinisha Ranna,Wim J. E. Tissing,Anusha Vaddi,Rachel Lubart,Cesar A. Migliorati,Rajesh V. Lalla,Karis Kin Fong Cheng,Sharon Elad,Isoo +17 more
TL;DR: The evidence supports the use of specific settings of PBM therapy for the prevention of OM in specific patient populations and No Guideline Possible for treatment of established OM or for management of chemotherapy-related OM is recommended.
A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis
Jan Magnus Bjordal,René-Jean Bensadoun,Jan Tunér,Lucio Frigo,Kjersti Gjerde,Rodrigo Álvaro Brandão Lopes-Martins,Rodrigo Álvaro Brandão Lopes-Martins +6 more
TL;DR: There is consistent evidence from small high-quality studies that red and infrared LLLT can partly prevent development of cancer therapy-induced OM.
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A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation
Mark M. Schubert,Mark M. Schubert,Mark M. Schubert,Fernanda de Paula Eduardo,Katherine A. Guthrie,Jean Claude Franquin,Rene Jean Bensadoun,Cesar A. Migliorati,C. Michele E. Lloid,Carlos de Paula Eduardo,Niccoli Filho Walter,Márcia Martins Marques,Mohd Hamdi +12 more
TL;DR: The 650 nm wavelength reduced the severity of oral mucositis and pain scores and low level laser therapy was well-tolerated and no adverse events were noted.
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