Journal Article10.1016/S1388-1981(00)00119-0
Phospholipase A(2)s and lipid peroxidation.
Santosh Nigam,Tankred Schewe +1 more
203
TL;DR: It is proposed that the platelet activating factor (PAF) acetylhydrolases of type II, which cleave preferentially peroxidised or lipoxygenated phospholipids, are competent for theospholipid repair, irrespective of their role in PAF metabolism.
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About: This article is published in Biochimica et Biophysica Acta. The article was published on 31 Oct 2000. The article focuses on the topics: Phospholipase A & Phospholipase.
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Citations
Oxidative stress and neurodegeneration: where are we now?
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Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
TL;DR: These aldehydes exhibit great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra and intermolecular covalent adducts, which can diffuse within or even escape from the cell and attack targets far from the site of the original event.
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Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
TL;DR: Results are consistent with the notion of a coupling of the oxidative environment in AD brain and increased risk of developing this disorder and strongly support a causative role of Abeta(1-42)-induced oxidative stress in AD neurodegeneration.
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Macrophage activation and its role in repair and pathology after spinal cord injury.
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TL;DR: This review compares and contrast the healing and inflammatory responses between spinal cord injuries and tissues that undergo complete wound resolution and identifies key macrophage phenotypes that are inaptly triggered or absent after spinal cord injury and discusses spinal cord stimuli that contribute to this maladaptive response.
693
References
Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes
TL;DR: The data presented indicate that the reticulocyte lipoxygenase in vivo acts on both plasma membranes and mitochondrial membranes, and that the hydroxy fatty acid content of the mitochondrial membranes is more than threefold higher than that of the plasma membranes.
43
Maturational Breakdown of Mitochondria and Other Organelles in Reticulocytes
Samuel M. Rapoport,Tankred Schewe,Bernd-Joachim Thiele +2 more
- 01 Jan 1990
TL;DR: The process best understood is the maturational breakdown of mitochondria in reticulocytes, which will therefore be the focus of the present review.
42
Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol.
Yunhi Cho,Vincent A. Ziboh +1 more
TL;DR: The data revealed that 13-HODE is incorporated into epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4, 5-P2) resulting in epidersmal phospholipase C-catalyzed release into a novel 13- HODE-containing diacylglycerol (1-acyl-2-13-Hode-glycerols).
42
Do specific linoleate 13-lipoxygenases initiate β-oxidation? 1
TL;DR: Findings may suggest that 13(S)‐H(P)ODE may constitute the endogenous substrate for β‐oxidation during lipid mobilization of oilseed plants.
42
Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine.
TL;DR: The relationship between lipid peroxidation and phospholipase A2 (PLA2) hydrolytic activity was studied using unilamellar vesicles (liposomes) as model membranes and there was a clear preference for PCperoxidation for all vesicle compositions tested and PC was preferentially hydrolyzed by PLA2.
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