Phosphatidylserine and the human brain

TL;DR: This review provides a comprehensive account of the properties, structures, and major sources of marine PLs, and provides focussed discussion of their relationship to brain health.

TL;DR: A detailed and up-to-date review on the sources, molecular species, and structures of food-derived phospholipids is presented and highlights the structure–activity relationship of phospholIPids and provides mechanistic insights into their biological activities.

TL;DR: It is concluded that there are disorders in which humans cannot synthesize L-serine in sufficient quantities, that L-Serine is effective in therapy of disorders associated with its deficiency, and that it should be classified as a “conditionally essential” amino acid.

TL;DR: The results showed that MET-PSL formulation could potentially act better than the free form of MET and PSL alone in the recovery process of rats with AD, and suggested that combination therapy of metformin-loaded phosphatidylserine liposomes may enhance the therapeutic performance in AD patients of a clinical study.

TL;DR: The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis.

TL;DR: Targeted disruption of each PS synthase individually in mice demonstrated that neither enzyme is required for viability whereas elimination of both synthases was embryonic lethal, indicating that mammalian cells require a threshold amount of PS.

TL;DR: In this paper, the authors focus on genes and enzymes involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss the available information on the regulation of PS biosynthetic in these organisms.

TL;DR: MRI-based hippocampal volumetry accurately depicts the structural–functional relationships between memory loss and hippocampal damage across the spectrum from normal aging to dementia.