Phenotypic variation amongst genotypically homogeneous Legionella pneumophila serogroup 1 isolates: implications for the investigation of outbreaks of Legionnaires' disease.
TL;DR: The data presented indicate that phenotypic variation of a single parent strain can occur within an environmental site and the implications are discussed in relation to the investigation of outbreaks of Legionnaires' disease.
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Abstract: One hundred and seventy-nine isolates of Legionella pneumophila serogroup 1, obtained from a site associated with an outbreak of Legionnaires' disease, were examined by monoclonal antibody subgrouping, restriction fragment length polymorphism typing, restriction endonuclease analysis and plasmid content. Nine distinct phenotypes were detected but at the genotypic level all strains were closely related. The data presented indicate that phenotypic variation of a single parent strain can occur within an environmental site. The implications of these findings are discussed in relation to the investigation of outbreaks of Legionnaires' disease.
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Distribution of Legionella pneumophila serogroups, monoclonal antibody subgroups and DNA sequence types in recent clinical and environmental isolates from England and Wales (2000–2008)
TL;DR: This study confirms previous work showing that just a few strains of L. pneumophila cause the majority of community-acquired Legionella infection in England and Wales, and that these clinically significant strains are only rarely found in managed water systems.
153
Legionella pneumophila Serogroup 1 Strain Paris: Endemic Distribution throughout France
Helena Aurell,Jerome Etienne,Françoise Forey,M. Reyrolle,Pascale Girardo,Pierre Farge,B Decludt,C. Campèse,François Vandenesch,Sophie Jarraud +9 more
TL;DR: An analysis of 691 French clinical Legionella isolates showed that the endemic L. pneumophila serogroup 1 strain Paris was responsible for 12.2% of all cases of legionellosis and had a specific pulsed-field gel electrophoresis pattern.
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Intraclonal Polymorphism in Bacteria
TL;DR: Ultimately, phenotypic plasticity reflects altered gene expression and it is the essence and subtleties of these genetically determined adaptations which are addressed in this chapter.
51
A comparison of Legionella pneumophila occurrence in hot water tanks and instantaneous devices in domestic, nosocomial, and community environments.
F. Martinelli,Arnaldo Caruso,Lina Moschini,Adolfo Turano,Carmelo Scarcella,Fabrizio Speziani +5 more
TL;DR: Differences in L. pneumophila isolation reflected different temperatures registered at the faucet: ≤50°C for hot water from reservoir devices, and >60°C from instantaneous devices, thus inhibiting the formation of biofilm and L.neumophila colonization.
50
Molecular epidemiology of an outbreak of Legionnaires' disease associated with a cooling tower in Genova-Sestri Ponente, Italy
M. Castellani Pastoris,L. Ciceroni,R. Lo Monaco,Paola Goldoni,B. Mentore,G. Flego,L. Cattani,Simonetta Ciarrocchi,A. Pinto,Paolo Visca +9 more
TL;DR: The hypothesis that the infection was transmitted from one of the cooling towers to the indoor environment of the same building, to homes in proximity that had open windows, and to the streets is supported, and the outbreak confirms the risk of Legionnaires' disease posed by cooling towers.
47
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