Journal Article10.1016/J.RCL.2004.09.005
PET imaging of cellular proliferation
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TL;DR: Further mechanistic studies of the imaging agents and well-designed clinical trials will be important in moving PET proliferation imaging into what is likely to be a significant role in the care of cancer patients by providing a quantitative measure of tumor response to cytotoxic or cytostatic therapy.
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About: This article is published in Radiologic Clinics of North America. The article was published on 01 Jan 2005.
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Citations
PET of Glucose Metabolism and Cellular Proliferation in Prostate Cancer.
TL;DR: Despite the seemingly prevalent notion that 18F-FDG PET may not be useful in prostate cancer, relatively limited evidence suggests that this imaging modality can be useful for the evaluation of the extent of metastatic disease and the assessment of the therapy response and prognosis in men with castration-resistant prostate cancer.
Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies.
TL;DR: The full utility of imaging the σ2 receptor status of solid tumors in the diagnosis and prediction of cancer therapeutic response will rely on elucidation of the functional role of this protein in normal and tumor cell biology.
Molecular imaging to guide systemic cancer therapy: Illustrative examples of PET imaging cancer biomarkers.
TL;DR: The utility of PET greatly expands when utilized as a biomarker, the topic of this review, to measure target expression to select subsets of patients who would most benefit from targeted therapy and measure early treatment response to predict therapeutic efficacy.
Role of PET quantitation in the monitoring of cancer response to treatment: Review of approaches and human clinical trials.
TL;DR: The aim of this review is to summarize the impact of commonly selected PET quantitation methods on the ability of PET measures to quantitate cancer response to treatment.
References
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Anthony F. Shields,John R. Grierson,B M Dohmen,Hans Jürgen Machulla,J C Stayanoff,Jawana M. Lawhorn-Crews,Joyce E. Obradovich,Otto Muzik,Thomas J. Mangner +8 more
TL;DR: [F-18]FLT (3'-deoxy-3'-fluorothymidine) is developed and tested; it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.
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The basic science of oncology
Ian F. Tannock,Richard P. Hill +1 more
- 14 Jun 1987
TL;DR: Tannock and Hill as mentioned in this paper reviewed the fast-moving and critically important scientific advances in cancer causation, cancer biology, and the biology underlying cancer treatment in the third edition of The Basic Science of Oncology.
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Thymidine Metabolism and Cell Kinetics
TL;DR: In this article, the authors presented Thymidine Metabolism and Cell Kinetics, and the International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 13, No. 2, pp. 204-204.
525
Regulation of human thymidine kinase during the cell cycle
James L. Sherley,Thomas J. Kelly +1 more
TL;DR: Two different post-transcriptional mechanisms largely account for the periodic behavior of the enzyme activity during the cell cycle, indicating that the efficiency of translation of thymidine kinase mRNA increases as cells begin DNA replication.
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