Journal Article10.1016/J.RCL.2004.09.005
PET imaging of cellular proliferation
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TL;DR: Further mechanistic studies of the imaging agents and well-designed clinical trials will be important in moving PET proliferation imaging into what is likely to be a significant role in the care of cancer patients by providing a quantitative measure of tumor response to cytotoxic or cytostatic therapy.
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About: This article is published in Radiologic Clinics of North America. The article was published on 01 Jan 2005.
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Citations
•Journal Article
[18F]FDG and [18F]FLT PET-CT and MR imaging of human neuroblastomas in a SCID mouse xenograft model.
Ursula Valentiner,Christina Haane,Kersten Peldschus,Heike Gustke,Winfried Brenner,Florian Wilke,Andreas Pommert,Michael Owsijewitsch,Udo Schumacher,Susanne Klutmann +9 more
TL;DR: Both MR and PET-CT imaging with [18F]FLT are highly qualified for the detection of neuroblastomas grown in SCID mice, however, [ 18F]FDG, which is the standard tracer in clinical PET-ct imaging, is not suited for PET- CT imaging in the neuroblastoma model.
7
Preclinical evaluation of investigational radiopharmaceutical RISAD-P intended for use as a diagnostic and molecular radiotherapy agent for prostate cancer
Zbigniew P. Kortylewicz,Elizabeth Mack,Charles A. Enke,Katherine A. Estes,R. Lee Mosley,Janina Baranowska-Kortylewicz +5 more
TL;DR: The preclinical toxicity and targeting potential of RISAD‐P was evaluated and the reagent was approved for molecular radiotherapy with Auger electron‐emitting radionuclides.
6
Proliferation imaging to measure early cancer response to targeted therapy.
David A. Mankoff,Janet F. Eary +1 more
TL;DR: The biological basis for proliferation imaging is reviewed and recent results using 18F-fluorothymidine-positron emission tomography to measure response to targeted therapy in the context of prior studies and potential future applications are discussed.
5
Effects of structural differences between radioiodine-labeled 1-(2′-fluoro-2′-deoxy-d-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2′-fluoro-2′-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging
Eun-Jung Kim,Su Hee Hong,Tae Hyun Choi,Eun Ah Lee,Kyeong Min Kim,Kyo Chul Lee,Gwang Il An,Mohammed I. El-Gamal,Mohammed I. El-Gamal,Gi Jeong Cheon,Chang Woon Choi,Sang Moo Lim +11 more
TL;DR: Evaluated structural differences between FIAU and FIRU showed that, as an imaging agent for HSV1-TK-expressing cells, radiolabeled FIAU was more efficient for in vivo imaging than FIRU.
5
References
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Anthony F. Shields,John R. Grierson,B M Dohmen,Hans Jürgen Machulla,J C Stayanoff,Jawana M. Lawhorn-Crews,Joyce E. Obradovich,Otto Muzik,Thomas J. Mangner +8 more
TL;DR: [F-18]FLT (3'-deoxy-3'-fluorothymidine) is developed and tested; it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.
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The basic science of oncology
Ian F. Tannock,Richard P. Hill +1 more
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TL;DR: Tannock and Hill as mentioned in this paper reviewed the fast-moving and critically important scientific advances in cancer causation, cancer biology, and the biology underlying cancer treatment in the third edition of The Basic Science of Oncology.
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Thymidine Metabolism and Cell Kinetics
TL;DR: In this article, the authors presented Thymidine Metabolism and Cell Kinetics, and the International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 13, No. 2, pp. 204-204.
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Regulation of human thymidine kinase during the cell cycle
James L. Sherley,Thomas J. Kelly +1 more
TL;DR: Two different post-transcriptional mechanisms largely account for the periodic behavior of the enzyme activity during the cell cycle, indicating that the efficiency of translation of thymidine kinase mRNA increases as cells begin DNA replication.
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