Perspectives on Daptomycin Resistance, with Emphasis on Resistance in Staphylococcus aureus
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TL;DR: The available data support the use of daptomycin in the treatment of methicillin-resistant S. aureus bacteremia and endocarditis, and findings of in vitro studies suggest a correlation between the minimum inhibitory concentrations of d aptomycin and vancomycin.
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Abstract: Methicillin-resistant Staphylococcus aureus infections are becoming more frequent and less easily treated by means of currently recommended agents. Vancomycin has been associated with decreased susceptibility in staphylococci and with treatment failures. Daptomycin is rapidly bactericidal; a dosage of 4 mg/kg daily is approved for treatment of skin and soft-tissue infections, and a dosage of 6 mg/kg daily is approved for treatment of patients with S. aureus bacteremia and right-sided endocarditis. Findings of in vitro studies suggest a correlation between the minimum inhibitory concentrations of daptomycin and vancomycin. Clinical failure was associated with increasing minimum inhibitory concentrations in case reports and in a randomized study of persons with S. aureus bacteremia and endocarditis. Patients who did not respond to therapy had deep-seated infections that required but could not be or were not managed with adjunctive surgical therapy. No definitive resistance mechanism has been identified, although genetic mutations have been described. Clinically, prior vancomycin therapy has not been associated with failure of daptomycin therapy. Although clinical practitioners must monitor for daptomycin resistance, the available data support the use of daptomycin in the treatment of methicillin-resistant S. aureus bacteremia and endocarditis.
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Citations
One Drug Multiple Targets: An Approach To Predict Drug Efficacies on Bacterial Strains Differing in Membrane Composition
Ayan Majumder,Malay Ranjan Biswal,Meher K. Prakash +2 more
- 07 Mar 2019
TL;DR: A complementary approach, one drug multiple targets, is developed and quantitatively illustrate it for a specific case of antibiotic targeting membranes, hint at the activity of daptomycin by interacting with the outer leaflet of the membrane.
7
Synthesis, biological evaluation and structure-activity relationships of 5-arylidene tetramic acids with antibacterial activity against methicillin-resistant Staphylococcus aureus.
Dimitris Matiadis,Dimitrios Tsironis,Valentina Stefanou,Spyridon Boussias,Angeliki Panagiotopoulou,Vickie McKee,Olga Igglessi-Markopoulou,John Markopoulos +7 more
TL;DR: The synthesis of a small library of 3-subsituted-5-arylidene tetramic acids is reported, which showed moderate to high activity with minimum inhibitory activity against methicillin-resistant Staphylococcus aureus and no human cell toxicity and hemolytic activity within the tested concentration range.
7
Twenty-seven-nucleotide repeat insertion in the rplV gene confers specific resistance to macrolide antibiotics in Staphylococcus aureus.
TL;DR: It is identified that a 27-nucleotide repeat sequence insertion in the rplV gene induced a specific resistance to macrolide antibiotics in S. aureus, and it is shown that the ectopic expression of the mutated rPLV gene containing the 27-nt repeat sequence inserted in several susceptible strains specifically conferred resistance tomacrolideiotics.
•Journal Article
Pilot Study Comparing Daptomycin And Telavancin In The Treatment Of Skin And Soft Tissue Infections
TL;DR: There did not appear to be any significant difference in clinical outcomes, rapidity of improvement, adverse events nor relapse rates in patients with lower extremity skin and soft tissue infections treated with daptomycin or telavancin.
One drug multiple targets: An approach to predict drug efficacies on bacterial strains differing in membrane composition
TL;DR: A quantitative model is developed for the activity of daptomycin on Streptococcus aureus strains with different membrane compositions, mainly varying in lysylation, which hints at an interaction of d aptomycin with the inner membrane.
6
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