Journal Article10.1016/J.BBCAN.2015.07.004
Personalized approaches to active immunotherapy in cancer
Eran Ophir,Sara Bobisse,George Coukos,George Coukos,Alexandre Harari,Alexandre Harari,Lana E. Kandalaft,Lana E. Kandalaft,Lana E. Kandalaft +8 more
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TL;DR: Combining next-generation personalized vaccination with other immunotherapy modalities might be the key for achieving significant therapeutic outcome.
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About: This article is published in Biochimica et Biophysica Acta. The article was published on 01 Jan 2016. The article focuses on the topics: Active immunotherapy & Immunotherapy.
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Citations
Harnessing the immune system to improve cancer therapy.
Nikos E. Papaioannou,Ourania V. Beniata,Panagiotis Vitsos,Ourania E. Tsitsilonis,Pinelopi Samara +4 more
TL;DR: The most popular cancer immunotherapy approaches are presented and their clinical relevance is discussed referring to data acquired from clinical trials.
Personalized neoantigen vaccines: a new approach to cancer immunotherapy
Amanda R. Aldous,Jesse Z. Dong +1 more
TL;DR: Current clinical trials using neoantigen targeting cancer vaccines, including in combination with checkpoint blockade monoclonal antibodies, have demonstrated potent T-cell responses against those neoantigens accompanied by antitumor effects in patients.
102
Hybrid Vesicles Based on Autologous Tumor Cell Membrane and Bacterial Outer Membrane To Enhance Innate Immune Response and Personalized Tumor Immunotherapy
TL;DR: In this paper, a vesicle system was designed to enhance the innate immune response and amplify personalized immunotherapy by hybridizing the bacterial outer membrane vesicles (OMV) with the cell membrane originated from the tumor (mT).
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A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma—A Proof of Antigen Discovery Feasibility in Three Patients
Michal Bassani-Sternberg,Michal Bassani-Sternberg,Antonia Digklia,Florian Huber,Florian Huber,D. Wagner,Christine Sempoux,Brian Stevenson,Anne-Christine Thierry,Justine Michaux,Justine Michaux,HuiSong Pak,HuiSong Pak,Julien Racle,Julien Racle,Caroline Boudousquié,Klara Balint,Klara Balint,George Coukos,George Coukos,David Gfeller,David Gfeller,Silvia Martin Lluesma,Silvia Martin Lluesma,Alexandre Harari,Alexandre Harari,Nicolas Demartines,Lana E. Kandalaft,Lana E. Kandalaft +28 more
TL;DR: It is hypothesized that effective vaccination in pancreatic cancer patients, along with interventions that can reprogram important immunosuppressive factors in the tumor microenvironment, can enhance tumor immune recognition, thus enhancing response to PD-1/PD-L1 blockade.
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Cancer Vaccines in Ovarian Cancer: How Can We Improve?
TL;DR: Past vaccination methods used in ovarian cancer are analyzed, different suggestions aiming to improve their efficacy in future trials are provided, and new strategies for the treatment of different cancers are considered.
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References
Enhanced Stimulation of Anti-Ovarian Cancer CD8+ T Cells by Dendritic Cells Loaded with Nanoparticle Encapsulated Tumor Antigen
Douglas Hanlon,Paulomi Aldo,Lesley Devine,Ayesha B. Alvero,Anna K. Engberg,Richard L. Edelson,Gil Mor +6 more
TL;DR: Enhanced stimulation of anti‐ovarian cancer CD8+ T cells by dendritic cells loaded with nanoparticle encapsulated tumor antigen by dendedritic cellsLoaded tumor antigen induces T cell reprograming.
Indoleamine 2,3-Dioxygenase in Tumor Induced Tolerance.
Liu Xiao-qian,Wang Xin +1 more
TL;DR: Recent studies reveal indoleamine 2,3-dioxygenase (IDO) plays a crucial role in tumor-induced tolerance, up-regulated in tumors and lymph nodes, and closely linked to regulatory T cells, promoting acquired tolerance through a positive feedback system.
Differential acquisition of antigenic peptides by Hsp70 and Hsc70 under oxidative conditions.
TL;DR: The chaperoning activity of purified Hsp70 and Hsc70 is minimal under reducing conditions and increases in environments that mimic oxidative stress, supporting the idea that formation of HSP70-peptide complexes and possibly their immunogenicity is enhanced in conditions of stress.
A Quadrivalent Vaccine Against Human Papillomavirus Prevented Anogenital Diseases in Young Women.
Jeff Andrews
TL;DR: A quadrivalent human papillomavirus (HPV) vaccine prevented anogenital diseases in young women, demonstrating its efficacy in reducing the incidence of HPV-related cancers and lesions.
•Journal Article
Immune and Clinical Responses in Patients with Metastatic Melanoma to CD34+ Progenitor-derived Dendritic Cell Vaccine
Jacques Banchereau,A. Karolina Palucka,Madhav V. Dhodapkar,Susan Burkeholder,Nicolas Taquet,Alexandre Rolland,Sybil Taquet,Sebastien Coquery,Knut M. Wittkowski,Nina Bhardwaj,L. Pineiro,Ralph M. Steinman,Joseph W. Fay +12 more
TL;DR: The overall immunity to MelAgs after DC vaccination is associated with clinical outcome (P = 0.015), and of 17 patients with evaluable disease, 6 of 7 patients with immunity to two or less Mel Ags had progressive disease 10 weeks after study entry, in contrast to tumor progression in only 1 of 10 patients with Immunity to >2 MelAgS.
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