Journal Article10.1159/000046876
Peroxynitrite-mediated mitochondrial dysfunction.
Jorge Boczkowski,Constanza Lisdero,Sophie Lanone,Maria Cecilia Carreras,Michel Aubier,Juan José Poderoso +5 more
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TL;DR: Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury.
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Abstract: Peroxynitrite anion (ONOO–) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms
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Citations
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
TL;DR: This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
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Gerwyn Morris,Michael Berk +1 more
TL;DR: Mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders are detailed.
Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress.
María Dolores Mauricio,Solanye Guerra-Ojeda,Patricia Marchio,Soraya L. Valles,Martin Aldasoro,Irene Escribano-Lopez,José Raúl Herance,Milagros Rocha,Jose Mª Vila,Victor M. Victor +9 more
TL;DR: The types of nanoparticles according to their chemical composition and the general characteristics of their use in medicine are summarized and nanoparticles with antioxidant properties may improve vascular dysfunction associated with hypertension, diabetes mellitus, or atherosclerosis.
References
Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
TL;DR: It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.
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The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
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