Peroxisome Proliferator-activated Receptor-γ-independent Inhibition of Macrophage Activation by the Non-thiazolidinedione Agonist L-796,449
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TL;DR: Treatment of activated macrophages with compound G enhanced the synthesis of superoxide anion, which, in combination with the NO produced under activation conditions, triggered apoptosis through the intracellular synthesis of peroxynitrite, suggesting that compound G might contribute to the resolution of inflammation by favoring the induction of apoptosisthrough mechanisms independent of PPAR-γ engagement.
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About: This article is published in Journal of Biological Chemistry. The article was published on 07 Sep 2001. and is currently open access. The article focuses on the topics: IκB kinase & IκBα.
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Citations
PPARs and the cardiovascular system.
TL;DR: A better understanding ofPPAR-dependent and -independent signaling will provide the foundation for future research on the role of PPARs in human cardiovascular biology.
PPARγ signaling exacerbates mammary gland tumor development
Enrique Saez,John M. Rosenfeld,Antonia Livolsi,Peter Olson,Eleuterio Lombardo,Michael C. Nelson,Ester Banayo,Robert D. Cardiff,Juan Carlos Izpisua-Belmonte,Ronald M. Evans +9 more
TL;DR: It is suggested that once an initiating event has taken place, increased PPARγ signaling serves as a tumor promoter in the mammary gland.
Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation.
Basilia Zingarelli,James A. Cook +1 more
TL;DR: The potential efficacy of PPARγ ligands as novel therapeutic approaches beyond diabetes in sepsis, inflammation, and reperfusion injury is emphasized.
153
Novel high-affinity PPARγ agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1
John A. Copland,Laura A. Marlow,S Kurakata,K Fujiwara,A K C Wong,Pamela A. Kreinest,Sandra F. Williams,Bryan R. Haugen,Joshua P. Klopper,Robert C. Smallridge +9 more
TL;DR: It is demonstrated that RS5444, a thiazolidinedione (Tzd) derivative, alone or in combination with paclitaxel, may provide therapeutic benefit to patients diagnosed with ATC and indicates that functional PPARγ is a molecular target for therapy in ATC.
150
Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection.
Cristina Romera,Olivia Hurtado,Judith Mallolas,Marta P. Pereira,Jesús R Morales,Alejandro Romera,Joaquín Serena,José Vivancos,Florentino Nombela,Pedro Lorenzo,Ignacio Lizasoain,María A. Moro +11 more
TL;DR: Data show that the GLT1/EAAT2 glutamate transporter is a target gene of PPARγ leading to neuroprotection by increasing glutamate uptake, and six putative PPAR response elements (PPREs) in theglutamate transporter promoter are identified and, consistently, rosiglitazone increased fourfold GLT 1/EAat2 promoter activity.
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