Journal Article10.1016/J.YJMCC.2013.01.004
Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury
Zhe Tian,Keishi Miyata,Hirokazu Tazume,Hisashi Sakaguchi,Tsuyoshi Kadomatsu,Eiji Horio,Otowa Takahashi,Yoshihiro Komohara,Kimi Araki,Yoichiro Hirata,Yoichiro Hirata,Minoru Tabata,Shuichiro Takanashi,Motohiro Takeya,Hiroyuki Hao,Michio Shimabukuro,Masataka Sata,Michio Kawasuji,Yuichi Oike +18 more
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TL;DR: It is demonstrated that perivascular adipose tissue-secreted Angptl2 accelerates vascular inflammation and the subsequent CVD development and that maintaining a balance between pro- and anti-inflammatory adipokines likely protects non-CHD patients from developing CHD.
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About: This article is published in Journal of Molecular and Cellular Cardiology. The article was published on 01 Apr 2013. The article focuses on the topics: Adipose tissue & Adipose tissue macrophages.
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Citations
Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations.
TL;DR: It is well established that the cardiovascular risk of obesity is more strongly associated with visceral rather than subcutaneous adiposity, and Anthropometric variables that account for visceral adiposity have limited influence on this risk.
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Angiopoietin-Like Proteins: A Comprehensive Look
TL;DR: This report represents a systematic and updated appraisal of this family of proteins structurally similar to the angiopoietins, focusing on the main features of each ANGPTL.
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
TL;DR: The diverse signaling mediators and mechanisms adipose tissue utilizes to relay information to other organs are reviewed and recently identified adipokines (proteins, lipids, and metabolites) are discussed and the contributions of noncoding RNAs and EVs to the ever-increasing complexities of adipose tissues inter-organ communication are outlined.
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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer
Carmine Carbone,Geny Piro,Valeria Merz,Francesca Simionato,Raffaela Santoro,Camilla Zecchetto,Giampaolo Tortora,Davide Melisi +7 more
TL;DR: The current knowledge about the functions of the ANGPTL proteins in angiogenesis, cancer progression and metastasis is outlined, and the most recent evidences sustaining their role as prognostic or predictive biomarkers for cancer therapy are discussed.
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Association of fibrotic remodeling and cytokines/chemokines content in epicardial adipose tissue with atrial myocardial fibrosis in patients with atrial fibrillation.
Ichitaro Abe,Yasushi Teshima,Hidekazu Kondo,Haruka Kaku,Shintaro Kira,Yuki Ikebe,Shotaro Saito,Akira Fukui,Tetsuji Shinohara,Kunio Yufu,Mikiko Nakagawa,Naoki Hijiya,Masatsugu Moriyama,Tatsuo Shimada,Shinji Miyamoto,Naohiko Takahashi +15 more
TL;DR: The study demonstrated that fibrotic remodeling and cytokines/chemokines in peri-LA EAT were associated with atrial myocardial fibrosis as a substrate of AF and suggested that overexpression of Hif-1α and Angptl2 may be involved in these processes.
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