Journal Article10.1002/AOC.6021
Peripheral or nonperipheral tetra‐[4‐(9H‐carbazol‐9‐yl)phenoxy] substituted cobalt(II), manganese(III) phthalocyanines: Synthesis, acetylcholinesterase, butyrylcholinesterase, and α‐glucosidase inhibitory effects and anticancer activities
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About: This article is published in Applied Organometallic Chemistry. The article was published on 01 Jan 2021. The article focuses on the topics: Butyrylcholinesterase.
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A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes
Marzieh Sohrabi,Mohammadreza Binaeizadeh,Aida Iraji,Bagher Larijani,Mina Saeedi,Mohammad Mahdavi +5 more
TL;DR: In this paper, the inhibitory activity of first-row transition metal complexes toward α-glucosidase is reviewed and their probable mechanisms of action are discussed.
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Progress and Development of Carbazole Scaffold based as Potential Anti-Alzheimer Agents using MTDL Approach.
TL;DR: The present review entails the scientific data on carbazole hybrids as potential Anti-Alzheimer activities from 2007 to 2021, that have shown potential anti-AlZheimer activities through multiple target pathways thereby promising hope for new drug development to confront AD.
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Synthesis and in vitro α-glucosidase and cholinesterases inhibitory actions of watersolublemetallophthalocyanines bearing ({6-[3-(diethylamino)phenoxy]hexyl}oxy groups
TL;DR: In this article , peripherally tetra-({6-[3-(diethylamino)phenoxy]hexyl}oxy substituted cobalt(II), copper(II, manganese(III) phthalocyanines (3, 4, 5) and their water-soluble derivatives (3a, 4a, 5a) were examined using spectrophotometric methods.
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Synthesis, characterization and α‐glucosidase, cholinesterases, tyrosinase inhibitory effects of axial substituted silicon and peripheral tetra‐substituted copper (II), manganese (III) phthalocyanines
TL;DR: In this article , axially di-(3,3-diphenylpropoxy) substituted silicon (DFP-Si) and peripherally tetra-(3-3-dimethylpropoxy)-substituted copper (II), manganese (III) phthalocyanines (Dfp-Cu, DFP-Mn) were synthesized and analyzed using spectrophotometric methods.
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Physical–chemical studies of new, versatile carbazole derivatives and zinc complexes: Their synthesis, investigation of in–vitro inhibitory effects on α –glucosidase and human erythrocyte carbonic anhydrase I and II isoenzymes
TL;DR: In this article , two novel zinc-phthalocyanine complexes (4a and 6a), containing carbazole rings, were investigated, and the inhibitory effects of these new Pcs and their ligands (3, 4, 5, and 6) on human erythrocytes carbonic anhydrase I and II (hCA II) isoenzymes were investigated.
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References
Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
TL;DR: An overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning.
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Metallophthalocyanines. gas sensors, resistors and field effect transistors
TL;DR: In this paper, the same type of studies have been carried out using metallophthalocyanine as the electroactive (semiconductive) part of a field effect transistor (FET).
424
Enzyme inhibition by metal complexes: concepts, strategies and applications
Kelly J. Kilpin,Paul J. Dyson +1 more
TL;DR: The main modes of enzyme inhibition by metal-based complexes are classified and the enzyme inhibition activity to macroscopic properties such as anticancer activity is correlated.
Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
TL;DR: Recent experimental evidence regarding diabetes and cognitive impairment is discussed and potential nutritional intervention strategies for the prevention and/or treatment of diabetes-related dementia are suggested.
Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline.
TL;DR: Fundamental past and ongoing research on diabetes-associated cognitive decline is summarized, highlighting potential contributors, mechanistic mediators, and new pharmacological approaches to prevent and/or delay this complication.
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