Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Carmen Z. Michaylira,Gabrielle S. Wong,Charles G. Miller,Christie M. Gutierrez,Hiroshi Nakagawa,Rachel Hammond,Andres J. Klein-Szanto,Ju Seog Lee,Sang Bae Kim,Meenhard Herlyn,J. Alan Diehl,J. Alan Diehl,Phyllis A. Gimotty,Anil K. Rustgi +13 more
TL;DR: These studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer.
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Abstract: Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molecule, is a key component of a novel tumor-invasive signature obtained from an organotypic culture model of engineered ESCC. This tumor-invasive signature classifies with human ESCC microarrays, underscoring its utility in human cancer. Genetic modulation of periostin promotes tumor cell migration and invasion as revealed in gain-of-loss and loss-of-function experiments. Inhibition of epidermal growth factor receptor signaling and restoration of wild-type p53 function were each found to attenuate periostin, suggesting the interdependence of two common genetic alterations with periostin function. Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer.
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Citations
Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
TL;DR: The characteristics of 3D cell culture systems in comparison to the two-dimensional monolayer culture are discussed, focusing on cell growth conditions, cell proliferation, population, and gene and protein expression profiles.
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
Wenchao Zhou,Susan Q. Ke,Zhi Huang,William A. Flavahan,Xiaoguang Fang,Jeremy Paul,Ling Wu,Andrew E. Sloan,Roger E. McLendon,Xiaoxia Li,Jeremy N. Rich,Shideng Bao +11 more
TL;DR: It is demonstrated that GSCs secrete periostin (POSTN) to recruit TAMs and found that TAMs in GBMs are not brain-resident microglia, but mainly monocyte-derived macrophages from peripheral blood.
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma
TL;DR: Advances in diagnostic techniques such as magnifying endoscopy with narrow band imaging or positron emission tomography have increased the accuracy of diagnosis of ESCC and advances gained from basic and clinical research are reviewed.
504
Immune microenvironment of gliomas.
Anna Gieryng,Dominika Pszczolkowska,Kacper Adam Walentynowicz,Wenson D. Rajan,Bozena Kaminska +4 more
TL;DR: The immunological aspects of glioma microenvironment, in particular composition and various roles of the immune cells infiltrating malignant human and experimental rodent gliomas, are reviewed.
455
The role of periostin in tissue remodeling across health and disease.
Simon J. Conway,Kenji Izuhara,Yasusei Kudo,Judith Litvin,Roger R. Markwald,Gaoliang Ouyang,Joseph R. Arron,Cecile T.J. Holweg,Akira Kudo +8 more
TL;DR: It is proposed that mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease, is proposed.
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References
Transduction of a Mesenchyme-specific Gene Periostin into 293T Cells Induces Cell Invasive Activity through Epithelial-Mesenchymal Transformation
TL;DR: An active role for periostin in EMT and metastasis that requires cross-talk between integrin and EGFR signaling pathways is demonstrated.
Revisão / review molecular aspects of esophageal squamous cell carcinoma carcinogenesis
Dárcio Matenhauer Lehrbach,Marcelo Eidi Nita,Ivan Cecconello +2 more
- 01 Jan 2003
TL;DR: Better understanding of molecular alterations during carcinogenesis is expected to improve tumor control and prevention and also may lead to better disease management.
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
Tatiana V. Tkatchenko,Ricardo A. Moreno-Rodriguez,Simon J. Conway,Jeffery D. Molkentin,Roger R. Markwald,Andrei V. Tkatchenko +5 more
TL;DR: It is found that lack of periostin in the embryonic OFT leads to ectopic expression of the proosteogenic growth factor pleiotrophin (Ptn) and overexpression of delta-like 1 homolog (Dlk1) in the distal (prevalvular) cushions of the OFT.
Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis
Tetsuro Nakazawa,Arata Nakajima,Naohiko Seki,Akihiko Okawa,Masaki Kato,H. Moriya,Norio Amizuka,Thomas A. Einhorn,Masashi Yamazaki +8 more
TL;DR: It is suggested that periostin is a specific marker for preosteoblasts and may play an important role in periOSTeal callus formation during the early stage of fracture healing.