Peptides affecting gonadal function

TL;DR: In this paper, the alpha amino groups of the amino acids used in solid phase synthesis of thymosin α 1 were removed with 5-10% trifluoroacetic acid in CH 2 Cl 2.

TL;DR: In this article, new gonadoliberin derivatives of the formula (I) Glp-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y, where Y represents a glycine-amide group or an -NH-alkyl group having 1 to 4 carbon atoms in the alkyl moiety, X stands for a D-thyroxyl, Dthyronyl or D-4-chlorophenylalanyl group, and acid addition salts and metal complexes thereof.

TL;DR: In this article, a method for inducing sterility in fish by administering at least one compound that disrupts the establishment of the gonadotropin-releasing hormone system during early development was presented.

TL;DR: In this article, a group of synthesized peptides that are analogs of the decapeptide GnRH are presented, where there is at least one residue of an unnatural amino acid in the 3-, 5-, 6- and/or 8-position.

Abstract: [im-Bzl D-His 6 ]LRF and [D-His 6 (im-Bzl), Pro 9 -NEt]LRF exhibit hydrophillicity comparable to that of LRF and act as superagonists exhibiting potencies, respectively, about 12 and more than 200 times that of LRF. The peptides or their nontoxic salts can be administered by intravenous subcutaneous, sublingual, oral, intravaginal, intranasal or rectal routes. The peptides can be used to regulate fertility in male and female mammals, including human beings.

TL;DR: In this paper, nonapeptide analogs of LH-RH of the formula (pyro)Glu-His-V-Ser-W-X-Y-Arg-Pro-Z (I) and the pharmaceutically acceptable salts thereof were presented.

TL;DR: The decapeptide [D-Phe6]-LH-RH, salts thereof, and intermediates used for the synthesis thereof are disclosed in this paper, where it is shown that the decAPEptide has potent LH- and FSH-releasing hormone properties.

TL;DR: In this paper, the authors proposed a peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine or NH-alkyl group with 1-3 carbon atoms or a NH-cyclopropyl group.