Journal Article10.1006/BBRC.1993.1844
Peptide growth factors markedly decrease the ligand binding of angiotensin II type 2 receptor in rat cultured vascular smooth muscle cells.
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TL;DR: This study indicated that the expression of AT2 is downregulated in cultured vascular smooth muscle cells by growth factors in contrast to that of AT1, which was slightly upregulated.
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About: This article is published in Biochemical and Biophysical Research Communications. The article was published on 15 Jul 1993. The article focuses on the topics: Vascular smooth muscle & Platelet-derived growth factor.
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Citations
•Journal Article
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
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Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases
TL;DR: The regulation of AT2-R expression, its cellular localization, its pathological role in cardiovascular and kidney diseases, and pharmacotherapeutic effects of AT1-R stimulation are discussed.
495
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Robson A.S. Santos,Maria José Campagnole-Santos,Nilo César do Vale Baracho,Marco Antônio Peliky Fontes,Luciana Costa Silva,Liomar A.A. Neves,Djenane Ramalho de Oliveira,Sordaine M. Caligiorne,André Ricardo Vale Rodrigues,Carlos Gropen,Wania da Silva Carvalho,Ana Cristina Simões e Silva,Mahesh C. Khosla +12 more
TL;DR: Results show that A-779 is a potent and selective antagonist for Ang-(1-7), and data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-( 1-7).
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Angiotensin II Activates Matrix Metalloproteinase Type II and Mimics Age-Associated Carotid Arterial Remodeling in Young Rats
Mingyi Wang,Jing Zhang,Gaia Spinetti,Liqun Jiang,Robert E. Monticone,Di Zhao,Linda Cheng,Melissa Krawczyk,Mark I. Talan,Gianfranco Pintus,Edward G. Lakatta +10 more
TL;DR: Ang II-induced effects on MMP2, transforming growth factor-beta1, collagen, and VSMCs are central to the arterial remodeling that accompanies advancing age.
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Role of AT2 Receptors in Angiotensin II–Stimulated Contraction of Small Mesenteric Arteries in Young SHR
TL;DR: In SHR, in the phase of developing hypertension, enhanced Ang II-stimulated vascular contraction may be associated with changes in Ang II receptor status, as evidenced pharmacologically and by increased vascular AT2 receptor mRNA and protein expression.
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