Journal Article10.1080/09205063.2017.1394711
PCL and PCL-based materials in biomedical applications
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TL;DR: PCL is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification, and it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties.
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Abstract: Biodegradable polymers have met with an increasing demand in medical usage over the last decades. One of such polymers is poly(e-caprolactone) (PCL), which is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strength can be adjusted, and therefore, it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties. Degradation time of PCL is quite long, thus it is used mainly in the replacement of hard tissues in the body where healing also takes an extended period of time. It is also used at load-bearing tissues of the body by enhancing its stiffness. However, due to its tailorability, use of PCL is not restricted to one type of tissue and it can be extended to engineering of soft tissues by decreasing its molecular weight and degradation time. This review ou...
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Citations
Living Cationic Polymerization of ε-Caprolactone Catalyzed by a Metal-free Lewis Acid of Trityl Tetrafluoroborate
TL;DR: In this article , a living cationic ring-opening polymerization of polycaprolactone (PCL) catalyzed by a safe, inexpensive, and metal-free Lewis acid of trityl tetrafluoroborate was reported.
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Fabrication and Evaluation of Polycaprolactone Beads-on-String Membranes for Applications in Bone Tissue Regeneration
Jaime Santillán,Jaime Santillán,Emmanuel A. Dwomoh,Yaiel G. Rodríguez-Avilés,Samir A. Bello,Eduardo Nicolau,Eduardo Nicolau +6 more
- 29 Jan 2019
TL;DR: This work shows a low-cost fabrication method to produce a biodegradable scaffold with micro/nanostructured characteristics that favor cell adhesion, proliferation, maturation, and subsequent differentiation of osteoblasts.
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Biomechanical properties of a customizable TPU/PCL blended esophageal stent fabricated by 3D printing
TL;DR: In this article , a 3D printed TPU/Poly-ε-caprolactone (PCL) blended esophageal stent using melt blending method combined with 3D printing technique was developed.
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Random and aligned electrospun poly(ε-caprolactone) (PCL)/poly(1,8-octanediol-co-citrate) (POC) fiber mats for cardiac tissue engineering using benign solvents
Lena Vogt,Aldo R. Boccaccini +1 more
TL;DR: In this paper, random and aligned PCL/POC fiber mats were investigated with regard to their morphological and physico-chemical properties, their degradation behavior, and their cytocompatibility in vitro.
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