Journal Article10.1080/09205063.2017.1394711
PCL and PCL-based materials in biomedical applications
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TL;DR: PCL is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification, and it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties.
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Abstract: Biodegradable polymers have met with an increasing demand in medical usage over the last decades. One of such polymers is poly(e-caprolactone) (PCL), which is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strength can be adjusted, and therefore, it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties. Degradation time of PCL is quite long, thus it is used mainly in the replacement of hard tissues in the body where healing also takes an extended period of time. It is also used at load-bearing tissues of the body by enhancing its stiffness. However, due to its tailorability, use of PCL is not restricted to one type of tissue and it can be extended to engineering of soft tissues by decreasing its molecular weight and degradation time. This review ou...
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Citations
Optimised release of tetracycline hydrochloride from core-sheath fibres produced by pressurised gyration
TL;DR: In this paper , a core-sheath pressurised gyration technique was used to create antibacterial fiber patches (tetracycline hydrochloride, TEHCL) using polyvinyl pyrrolidone (PVP) and polycaprolactone(PCL).
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Facile manufacturing of fused-deposition modeled composite scaffolds for tissue engineering-an embedding model with plasticity for incorporation of additives.
Kamath S Manjunath,K. Sridhar,V Gopinath,Krishnakumar Sankar,A. Sundaram,Nilkantha Gupta,Ahmed S S J Shiek,Patil S Shantanu +7 more
TL;DR: 3D interlinked porous PLA scaffold was fabricated by FDM, followed by embedment of PCL scaffold into the pores of PLA at room temperature yielding PLA-PCL scaffold, which offers provision to incorporate desired concentrations of heat labile bioactive molecules during embedment process at ambient temperature.
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Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model
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TL;DR: In this paper, the authors tested poly(3-hydroxybutyrate-co-3hydroxyvalerate) poly(e-caprolactone) 4-mm-diameter vascular grafts equipped with vascular endothelial growth factor (VEGF), basic fibroblast growth factor and stromal cell-derived factor 1α (SDF-1α) and surface coated with heparin and iloprost (PHBV/PCL[VEGF-bFGF-SDF]Hep/Ilo, n = 8
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TL;DR: Biodegradable poly(ɛ-caprolactone) (PCL) and its composites/blends have potential applications in water treatment, packaging, and biomaterials.
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